======= CTSD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTSD
  * **<color #00a2e8>Official Name</color>**: cathepsin D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1509|1509]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07339|P07339]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTSD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTSD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/116840|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. {ECO:0000269|PubMed:27333034}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|A1 Propeptide|
|Asp|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|aspartic-type peptidase activity|
|lipoprotein catabolic process|
|aspartic-type endopeptidase activity|
|collagen catabolic process|
|tertiary granule lumen|
|specific granule lumen|
|collagen metabolic process|
|peptidase activity|
|lysosomal lumen|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|melanosome|
|lipoprotein metabolic process|
|ficolin-1-rich granule lumen|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of endopeptidase activity|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|positive regulation of peptidase activity|
|endosome membrane|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|antigen processing and presentation|
|membrane raft|
|regulation of cysteine-type endopeptidase activity|
|lysosome|
|lysosomal membrane|
|positive regulation of proteolysis|
|collagen-containing extracellular matrix|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|protein catabolic process|
|positive regulation of cell death|
|regulated exocytosis|
|regulation of proteolysis|
|regulation of establishment of protein localization|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|exocytosis|
|leukocyte activation|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cell activation|
|immune effector process|
|secretion|
|proteolysis|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|regulation of programmed cell death|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10302
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTSD Expression in NALM6 Cells: 6.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>