======= CTTN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTTN
  * **<color #00a2e8>Official Name</color>**: cortactin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2017|2017]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14247|Q14247]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTTN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTTN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164765|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 1|
|HS1 rep|
|SH3 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|site of polarized growth|
|substrate-dependent cell migration, cell extension|
|dendritic spine maintenance|
|profilin binding|
|mitotic spindle midzone|
|cortical cytoskeleton|
|cell-substrate adherens junction assembly|
|substrate-dependent cell migration|
|focal adhesion assembly|
|podosome|
|actin filament polymerization|
|dendritic spine organization|
|positive regulation of smooth muscle contraction|
|adherens junction assembly|
|neuron projection organization|
|regulation of autophagy of mitochondrion|
|lamellipodium organization|
|cell-substrate junction assembly|
|positive regulation of muscle contraction|
|cellular component maintenance|
|actin polymerization or depolymerization|
|cortical actin cytoskeleton|
|clathrin-coated pit|
|regulation of smooth muscle contraction|
|actin cytoskeleton reorganization|
|actin filament|
|adherens junction organization|
|voltage-gated potassium channel complex|
|protein polymerization|
|postsynapse organization|
|positive regulation of actin filament polymerization|
|ruffle|
|regulation of axon extension|
|negative regulation of extrinsic apoptotic signaling pathway|
|regulation of extent of cell growth|
|cell-matrix adhesion|
|positive regulation of protein polymerization|
|growth cone|
|cell cortex|
|dendritic spine|
|regulation of extrinsic apoptotic signaling pathway|
|regulation of muscle contraction|
|regulation of actin filament polymerization|
|cell junction assembly|
|lamellipodium|
|regulation of mitochondrion organization|
|regulation of cell size|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|cell-substrate adhesion|
|regulation of axonogenesis|
|positive regulation of supramolecular fiber organization|
|actin filament binding|
|cell junction organization|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|negative regulation of apoptotic signaling pathway|
|regulation of muscle system process|
|receptor-mediated endocytosis|
|actin filament organization|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|synapse organization|
|regulation of cell morphogenesis involved in differentiation|
|cadherin binding|
|regulation of developmental growth|
|regulation of autophagy|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|cytoskeleton|
|regulation of cellular component size|
|regulation of actin filament-based process|
|regulation of apoptotic signaling pathway|
|focal adhesion|
|regulation of cell growth|
|plasma membrane bounded cell projection assembly|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|cell projection assembly|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|cell part morphogenesis|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|endocytosis|
|actin filament-based process|
|regulation of system process|
|positive regulation of organelle organization|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|import into cell|
|intracellular membrane-bounded organelle|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|cell morphogenesis|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|membrane organization|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|regulation of cellular component biogenesis|
|cell migration|
|Golgi apparatus|
|intracellular protein transport|
|negative regulation of cell death|
|regulation of catabolic process|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|regulation of organelle organization|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.87|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7382
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTTN Expression in NALM6 Cells: 0.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>