======= CUL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CUL2
  * **<color #00a2e8>Official Name</color>**: cullin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8453|8453]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13617|Q13617]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CUL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CUL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603135|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). {ECO:0000269|PubMed:10973499, ECO:0000269|PubMed:11384984, ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:9122164}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cullin|
|Cullin Nedd8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|VCB complex|
|cullin-RING ubiquitin ligase complex|
|Cul2-RING ubiquitin ligase complex|
|SCF ubiquitin ligase complex|
|regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|regulation of DNA-templated transcription in response to stress|
|intrinsic apoptotic signaling pathway|
|cellular response to hypoxia|
|cellular response to decreased oxygen levels|
|cellular response to oxygen levels|
|protein-containing complex binding|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|apoptotic signaling pathway|
|ubiquitin protein ligase binding|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|response to hypoxia|
|proteasomal protein catabolic process|
|response to decreased oxygen levels|
|post-translational protein modification|
|response to oxygen levels|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|protein catabolic process|
|mitotic cell cycle|
|protein ubiquitination|
|viral process|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|nucleolus|
|cellular macromolecule catabolic process|
|apoptotic process|
|protein modification by small protein conjugation or removal|
|cell cycle process|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|cell death|
|response to abiotic stimulus|
|proteolysis|
|cell cycle|
|intracellular signal transduction|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2.76|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-2.54|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-2.35|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.24|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-2.21|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.19|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-2.08|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-2.08|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.06|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-2.06|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-2.05|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-2.02|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-1.97|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.97|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|-1.96|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.94|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.91|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.91|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.83|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.83|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.8|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.79|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.78|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-1.77|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.77|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|-1.76|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.76|
|[[:results:exp218|A-395 10μM R05 exp218]]|-1.75|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.73|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.71|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 312/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|13/28|
|blood|7/28|
|bone|12/26|
|breast|8/33|
|central nervous system|30/56|
|cervix|4/4|
|colorectal|2/17|
|esophagus|6/13|
|fibroblast|1/1|
|gastric|2/16|
|kidney|9/21|
|liver|9/20|
|lung|36/75|
|lymphocyte|5/16|
|ovary|13/26|
|pancreas|11/24|
|peripheral nervous system|13/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|17/24|
|soft tissue|6/9|
|thyroid|0/2|
|upper aerodigestive|11/22|
|urinary tract|12/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1986
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CUL2 Expression in NALM6 Cells: 6.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>