======= CUL4B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CUL4B
  * **<color #00a2e8>Official Name</color>**: cullin 4B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8450|8450]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13620|Q13620]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CUL4B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CUL4B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300304|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cullin Nedd8|
|Cullin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Cul4B-RING E3 ubiquitin ligase complex|
|cullin-RING ubiquitin ligase complex|
|UV-damage excision repair|
|histone H2A monoubiquitination|
|nucleotide-excision repair, preincision complex stabilization|
|nucleotide-excision repair, DNA incision, 3-to lesion|
|nucleotide-excision repair, DNA duplex unwinding|
|histone H2A ubiquitination|
|nucleotide-excision repair, DNA damage recognition|
|global genome nucleotide-excision repair|
|Cul4-RING E3 ubiquitin ligase complex|
|nucleotide-excision repair, preincision complex assembly|
|histone monoubiquitination|
|positive regulation of G1/S transition of mitotic cell cycle|
|nucleotide-excision repair, DNA incision, 5-to lesion|
|DNA damage response, detection of DNA damage|
|nucleotide-excision repair, DNA incision|
|histone ubiquitination|
|positive regulation of cell cycle G1/S phase transition|
|damaged DNA binding|
|protein monoubiquitination|
|SCF ubiquitin ligase complex|
|transcription-coupled nucleotide-excision repair|
|positive regulation of mitotic cell cycle phase transition|
|cellular response to UV|
|positive regulation of cell cycle phase transition|
|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|
|nucleotide-excision repair|
|DNA duplex unwinding|
|cellular response to light stimulus|
|G1/S transition of mitotic cell cycle|
|DNA geometric change|
|cell cycle G1/S phase transition|
|response to UV|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|regulation of cell cycle G1/S phase transition|
|cellular response to radiation|
|protein-DNA complex assembly|
|positive regulation of protein catabolic process|
|protein-DNA complex subunit organization|
|positive regulation of protein complex assembly|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|positive regulation of cell cycle process|
|ubiquitin protein ligase binding|
|DNA conformation change|
|nucleic acid phosphodiester bond hydrolysis|
|ribosome biogenesis|
|response to light stimulus|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|post-translational protein modification|
|histone modification|
|covalent chromatin modification|
|positive regulation of cell cycle|
|regulation of protein catabolic process|
|regulation of mitotic cell cycle phase transition|
|positive regulation of catabolic process|
|response to radiation|
|regulation of cell cycle phase transition|
|regulation of protein complex assembly|
|ribonucleoprotein complex biogenesis|
|DNA repair|
|positive regulation of cellular component biogenesis|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|neuron projection development|
|protein catabolic process|
|mitotic cell cycle|
|protein ubiquitination|
|detection of stimulus|
|chromatin organization|
|DNA metabolic process|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|neuron development|
|cellular protein-containing complex assembly|
|cellular macromolecule catabolic process|
|regulation of cellular component biogenesis|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|cell cycle process|
|neuron differentiation|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chromosome organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|proteolysis|
|cell cycle|
|generation of neurons|
|protein-containing complex assembly|
|neurogenesis|
|cell development|
|cellular response to stress|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-2.66|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-1.92|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.437|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/683
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/26|
|bone|0/25|
|breast|1/30|
|central nervous system|1/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|1/72|
|lymphocyte|0/14|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|1/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15479
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CUL4B Expression in NALM6 Cells: 5.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>