======= CUL5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CUL5
  * **<color #00a2e8>Official Name</color>**: cullin 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8065|8065]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q93034|Q93034]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CUL5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CUL5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601741|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cullin|
|Cullin Nedd8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Cul5-RING ubiquitin ligase complex|
|cullin-RING ubiquitin ligase complex|
|ERBB2 signaling pathway|
|calcium channel activity|
|SCF ubiquitin ligase complex|
|ERBB signaling pathway|
|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|intrinsic apoptotic signaling pathway|
|calcium ion transmembrane transport|
|signaling receptor activity|
|ubiquitin-protein transferase activity|
|calcium ion transport|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|apoptotic signaling pathway|
|ubiquitin protein ligase binding|
|divalent metal ion transport|
|divalent inorganic cation transport|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|post-translational protein modification|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|inorganic cation transmembrane transport|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cation transmembrane transport|
|cellular protein catabolic process|
|metal ion transport|
|inorganic ion transmembrane transport|
|protein catabolic process|
|mitotic cell cycle|
|protein ubiquitination|
|viral process|
|enzyme linked receptor protein signaling pathway|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|cation transport|
|cellular macromolecule catabolic process|
|apoptotic process|
|ion transmembrane transport|
|protein modification by small protein conjugation or removal|
|cell cycle process|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|cell death|
|proteolysis|
|transmembrane transport|
|cell cycle|
|ion transport|
|intracellular signal transduction|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-2.12|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.99|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.85|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.72|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.71|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.74|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.77|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.83|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.91|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4504
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CUL5 Expression in NALM6 Cells: 5.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>