======= CUL7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CUL7
  * **<color #00a2e8>Official Name</color>**: cullin 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9820|9820]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14999|Q14999]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CUL7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CUL7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609577|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (PubMed:20139075). Does not promote polyubiquitination and proteasomal degradation of p53/TP53 (PubMed:16547496, PubMed:17332328). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may be have additional functions. {ECO:0000269|PubMed:16547496, ECO:0000269|PubMed:17332328, ECO:0000269|PubMed:18498745, ECO:0000269|PubMed:20139075, ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cul7|
|APC10|
|Cullin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Cul7-RING ubiquitin ligase complex|
|3M complex|
|anaphase-promoting complex|
|positive regulation of dendrite morphogenesis|
|IRE1-mediated unfolded protein response|
|vasculogenesis|
|mitotic cytokinesis|
|epithelial to mesenchymal transition|
|positive regulation of dendrite development|
|regulation of dendrite morphogenesis|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|endoplasmic reticulum unfolded protein response|
|cellular response to unfolded protein|
|Golgi organization|
|cellular response to topologically incorrect protein|
|regulation of dendrite development|
|placenta development|
|positive regulation of cell morphogenesis involved in differentiation|
|mesenchymal cell differentiation|
|response to unfolded protein|
|regulation of mitotic nuclear division|
|response to topologically incorrect protein|
|regulation of nuclear division|
|mesenchyme development|
|response to endoplasmic reticulum stress|
|positive regulation of neuron projection development|
|ubiquitin protein ligase binding|
|regulation of cell morphogenesis involved in differentiation|
|post-translational protein modification|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|blood vessel morphogenesis|
|endomembrane system organization|
|reproductive structure development|
|reproductive system development|
|positive regulation of neurogenesis|
|microtubule cytoskeleton organization|
|blood vessel development|
|regulation of cell morphogenesis|
|centrosome|
|cell division|
|regulation of neuron projection development|
|vasculature development|
|cardiovascular system development|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|positive regulation of nervous system development|
|positive regulation of cell development|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|tube morphogenesis|
|regulation of neuron differentiation|
|developmental process involved in reproduction|
|microtubule-based process|
|mitotic cell cycle|
|protein catabolic process|
|protein ubiquitination|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|viral process|
|regulation of cell projection organization|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|symbiotic process|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|tube development|
|circulatory system development|
|cellular macromolecule catabolic process|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|Golgi apparatus|
|protein modification by small protein conjugation or removal|
|cell cycle process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|proteolysis|
|regulation of organelle organization|
|cell cycle|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|generation of neurons|
|neurogenesis|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2549
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CUL7 Expression in NALM6 Cells: 4.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>