======= CWC27 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CWC27
  * **<color #00a2e8>Official Name</color>**: CWC27 spliceosome associated cyclophilin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10283|10283]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6UX04|Q6UX04]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CWC27&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CWC27|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617170|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  PPIases accelerate the folding of proteins. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pro isomerase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cyclosporin A binding|
|peptidyl-prolyl cis-trans isomerase activity|
|protein peptidyl-prolyl isomerization|
|U2-type precatalytic spliceosome|
|peptidyl-proline modification|
|catalytic step 2 spliceosome|
|protein folding|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|peptidyl-amino acid modification|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-3.07|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-2.51|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-2.32|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.25|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.17|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.94|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-1.78|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.75|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.72|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.76|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.97|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|2.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cnot2|CNOT2]]|0.476|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11851
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CWC27 Expression in NALM6 Cells: 4.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>