======= CX3CR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CX3CR1
  * **<color #00a2e8>Official Name</color>**: C-X3-C motif chemokine receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1524|1524]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49238|P49238]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CX3CR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CX3CR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601470|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions (PubMed:9390561, PubMed:23125415). Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro) (PubMed:9726990). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1 (PubMed:14607932). {ECO:0000269|PubMed:14607932, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:9390561, ECO:0000269|PubMed:9726990}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srsx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|multiple spine synapse organization, single dendrite|
|multiple spine synapse organization|
|C-X3-C chemokine receptor activity|
|negative regulation of hippocampal neuron apoptotic process|
|dendritic tree|
|regulation of hippocampal neuron apoptotic process|
|C-X3-C chemokine binding|
|positive regulation of I-kappaB phosphorylation|
|regulation of I-kappaB phosphorylation|
|autocrine signaling|
|central nervous system maturation|
|regulation of microglial cell migration|
|synapse pruning|
|negative regulation of long-term synaptic potentiation|
|synapse maturation|
|regulation of glial cell migration|
|chemokine receptor activity|
|leukocyte tethering or rolling|
|leukocyte adhesion to vascular endothelial cell|
|positive regulation of neuroblast proliferation|
|C-C chemokine receptor activity|
|C-C chemokine binding|
|chemokine binding|
|negative regulation of interleukin-1 beta production|
|neuronal cell body membrane|
|regulation of tumor necrosis factor biosynthetic process|
|regulation of neuroblast proliferation|
|negative regulation of interleukin-1 production|
|regulation of macrophage migration|
|positive regulation of stem cell proliferation|
|cellular extravasation|
|G protein-coupled peptide receptor activity|
|regulation of long-term synaptic potentiation|
|response to ischemia|
|leukocyte cell-cell adhesion|
|intraspecies interaction between organisms|
|social behavior|
|positive regulation of neural precursor cell proliferation|
|cellular defense response|
|regulation of nitric oxide biosynthetic process|
|regulation of stem cell proliferation|
|multi-organism behavior|
|chemokine-mediated signaling pathway|
|regulation of interleukin-1 beta production|
|regulation of reactive oxygen species biosynthetic process|
|regulation of neural precursor cell proliferation|
|response to chemokine|
|cellular response to chemokine|
|regulation of interleukin-1 production|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|regulation of cytokine biosynthetic process|
|regulation of gliogenesis|
|negative regulation of vasculature development|
|memory|
|anatomical structure maturation|
|negative regulation of neuron apoptotic process|
|calcium-mediated signaling|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of NF-kappaB transcription factor activity|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|positive regulation of angiogenesis|
|positive regulation of protein kinase B signaling|
|regulation of reactive oxygen species metabolic process|
|positive regulation of vasculature development|
|cellular response to lipopolysaccharide|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of synaptic plasticity|
|cellular response to molecule of bacterial origin|
|regulation of leukocyte migration|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|cell chemotaxis|
|cellular response to biotic stimulus|
|regulation of protein kinase B signaling|
|negative regulation of apoptotic signaling pathway|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|developmental maturation|
|learning or memory|
|negative regulation of cell migration|
|positive regulation of DNA-binding transcription factor activity|
|synapse organization|
|negative regulation of cell motility|
|negative regulation of cytokine production|
|positive regulation of cytosolic calcium ion concentration|
|regulation of angiogenesis|
|cognition|
|negative regulation of cellular component movement|
|regulation of neuron death|
|response to lipopolysaccharide|
|neuron projection|
|regulation of vasculature development|
|negative regulation of locomotion|
|response to molecule of bacterial origin|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|regulation of neurotransmitter levels|
|leukocyte migration|
|external side of plasma membrane|
|regulation of apoptotic signaling pathway|
|cellular component disassembly|
|regulation of DNA-binding transcription factor activity|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|divalent inorganic cation homeostasis|
|cellular response to growth factor stimulus|
|cell-cell adhesion|
|cellular response to lipid|
|response to growth factor|
|positive regulation of nervous system development|
|positive regulation of cell development|
|chemotaxis|
|taxis|
|cellular metal ion homeostasis|
|response to wounding|
|behavior|
|cell surface|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cytokine-mediated signaling pathway|
|response to bacterium|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|viral process|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|cellular chemical homeostasis|
|innate immune response|
|symbiotic process|
|ion homeostasis|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|regulation of cell migration|
|response to lipid|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|defense response to other organism|
|cell migration|
|positive regulation of cell differentiation|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|response to cytokine|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13306
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CX3CR1 Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>