======= CXCL12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CXCL12
  * **<color #00a2e8>Official Name</color>**: C-X-C motif chemokine ligand 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6387|6387]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48061|P48061]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CXCL12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CXCL12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600835|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to ultrasound|
|CXCR chemokine receptor binding|
|chemokine (C-X-C motif) ligand 12 signaling pathway|
|negative regulation of leukocyte tethering or rolling|
|negative regulation of leukocyte adhesion to vascular endothelial cell|
|positive regulation of dopamine secretion|
|positive regulation of axon extension involved in axon guidance|
|negative regulation of dendritic cell apoptotic process|
|chemokine receptor binding|
|positive regulation of axon guidance|
|regulation of leukocyte tethering or rolling|
|negative regulation of cellular extravasation|
|integrin activation|
|regulation of dendritic cell apoptotic process|
|positive regulation of catecholamine secretion|
|detection of mechanical stimulus involved in sensory perception of pain|
|induction of positive chemotaxis|
|detection of temperature stimulus involved in sensory perception|
|detection of temperature stimulus involved in sensory perception of pain|
|positive regulation of monocyte chemotaxis|
|regulation of leukocyte adhesion to vascular endothelial cell|
|detection of temperature stimulus|
|positive regulation of calcium ion import|
|sensory perception of temperature stimulus|
|positive regulation of mononuclear cell migration|
|regulation of monocyte chemotaxis|
|positive regulation of positive chemotaxis|
|regulation of positive chemotaxis|
|detection of mechanical stimulus involved in sensory perception|
|regulation of cellular extravasation|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|positive regulation of response to drug|
|positive regulation of T cell migration|
|regulation of axon extension involved in axon guidance|
|positive regulation of amine transport|
|positive regulation of lymphocyte migration|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of calcium ion import|
|regulation of dopamine secretion|
|positive regulation of axon extension|
|regulation of axon guidance|
|detection of mechanical stimulus|
|regulation of T cell migration|
|negative regulation of leukocyte migration|
|negative regulation of leukocyte apoptotic process|
|regulation of mononuclear cell migration|
|chemokine activity|
|telencephalon cell migration|
|forebrain cell migration|
|regulation of catecholamine secretion|
|regulation of lymphocyte migration|
|animal organ regeneration|
|sensory perception of pain|
|adult locomotory behavior|
|negative regulation of response to DNA damage stimulus|
|chemokine-mediated signaling pathway|
|regulation of leukocyte apoptotic process|
|positive regulation of axonogenesis|
|positive regulation of leukocyte chemotaxis|
|cellular response to chemokine|
|response to chemokine|
|positive regulation of endothelial cell proliferation|
|regulation of amine transport|
|negative regulation of intrinsic apoptotic signaling pathway|
|regulation of axon extension|
|regulation of response to drug|
|response to heat|
|regulation of extent of cell growth|
|regulation of leukocyte chemotaxis|
|detection of external stimulus|
|neuron migration|
|positive regulation of calcium ion transport|
|negative regulation of leukocyte cell-cell adhesion|
|detection of abiotic stimulus|
|positive regulation of leukocyte migration|
|regulation of endothelial cell proliferation|
|integrin binding|
|positive regulation of chemotaxis|
|adult behavior|
|positive regulation of cell morphogenesis involved in differentiation|
|regeneration|
|regulation of intrinsic apoptotic signaling pathway|
|positive regulation of cell growth|
|growth factor activity|
|sensory perception of mechanical stimulus|
|positive regulation of developmental growth|
|negative regulation of cell-cell adhesion|
|response to temperature stimulus|
|regulation of cell size|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|regulation of axonogenesis|
|positive regulation of epithelial cell proliferation|
|locomotory behavior|
|regulation of leukocyte migration|
|cell chemotaxis|
|response to mechanical stimulus|
|regulation of chemotaxis|
|regulation of response to DNA damage stimulus|
|negative regulation of apoptotic signaling pathway|
|regulation of calcium ion transport|
|telencephalon development|
|positive regulation of growth|
|negative regulation of cell migration|
|axon guidance|
|regulation of actin filament organization|
|neuron projection guidance|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|positive regulation of ion transport|
|positive regulation of neuron projection development|
|response to virus|
|regulation of leukocyte cell-cell adhesion|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|regulation of developmental growth|
|regulation of epithelial cell proliferation|
|signaling receptor binding|
|regulation of actin cytoskeleton organization|
|response to hypoxia|
|regulation of supramolecular fiber organization|
|response to decreased oxygen levels|
|collagen-containing extracellular matrix|
|positive regulation of neuron differentiation|
|axonogenesis|
|regulation of cellular component size|
|response to oxygen levels|
|positive regulation of cell projection organization|
|regulation of metal ion transport|
|forebrain development|
|regulation of actin filament-based process|
|blood circulation|
|response to peptide hormone|
|external side of plasma membrane|
|circulatory system process|
|regulation of cell-cell adhesion|
|regulation of apoptotic signaling pathway|
|positive regulation of secretion by cell|
|positive regulation of cell adhesion|
|axon development|
|regulation of cell growth|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|response to radiation|
|negative regulation of immune system process|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|response to peptide|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|divalent inorganic cation homeostasis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|positive regulation of cell migration|
|negative regulation of intracellular signal transduction|
|regulation of anatomical structure size|
|cell part morphogenesis|
|positive regulation of cell motility|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|detection of stimulus involved in sensory perception|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|cell morphogenesis involved in differentiation|
|behavior|
|positive regulation of response to external stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|detection of stimulus|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|viral process|
|cation homeostasis|
|regulation of cell projection organization|
|inorganic ion homeostasis|
|cell morphogenesis|
|regulation of cellular response to stress|
|brain development|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|head development|
|symbiotic process|
|ion homeostasis|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|regulation of cell migration|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|cell migration|
|positive regulation of cell differentiation|
|sensory perception|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|negative regulation of cell death|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|regulation of response to external stimulus|
|response to cytokine|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|positive regulation of immune system process|
|response to abiotic stimulus|
|cell projection organization|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|response to endogenous stimulus|
|regulation of response to stress|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.7|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14313
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CXCL12 Expression in NALM6 Cells: -5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>