======= CYBB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYBB
  * **<color #00a2e8>Official Name</color>**: cytochrome b-245 beta chain
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1536|1536]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04839|P04839]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYBB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYBB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300481|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FAD binding 8|
|NAD binding 6|
|FAD binding 6|
|Ferric reduct|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to L-glutamine|
|response to L-glutamine|
|hypoxia-inducible factor-1alpha signaling pathway|
|response to aldosterone|
|hydrogen peroxide biosynthetic process|
|superoxide-generating NADPH oxidase activity|
|antibiotic biosynthetic process|
|cellular response to ethanol|
|NADPH oxidase complex|
|superoxide anion generation|
|perinuclear endoplasmic reticulum|
|respiratory burst|
|positive regulation of tumor necrosis factor biosynthetic process|
|reactive oxygen species biosynthetic process|
|response to angiotensin|
|regulation of tumor necrosis factor biosynthetic process|
|response to mineralocorticoid|
|hydrogen peroxide metabolic process|
|cellular response to cadmium ion|
|superoxide metabolic process|
|voltage-gated ion channel activity|
|flavin adenine dinucleotide binding|
|rough endoplasmic reticulum|
|response to cadmium ion|
|vascular endothelial growth factor receptor signaling pathway|
|cellular response to nutrient|
|positive regulation of cytokine biosynthetic process|
|cellular response to amino acid stimulus|
|tertiary granule membrane|
|phagocytic vesicle membrane|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|cell redox homeostasis|
|electron transfer activity|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|cellular response to alcohol|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|specific granule membrane|
|antigen processing and presentation of peptide antigen via MHC class I|
|antibiotic metabolic process|
|regulation of cytokine biosynthetic process|
|reactive oxygen species metabolic process|
|response to amino acid|
|cellular response to antibiotic|
|response to ethanol|
|heme binding|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|response to corticosteroid|
|positive regulation of angiogenesis|
|antigen processing and presentation of exogenous peptide antigen|
|nuclear envelope|
|electron transport chain|
|positive regulation of vasculature development|
|antigen processing and presentation of exogenous antigen|
|cellular response to hypoxia|
|antigen processing and presentation of peptide antigen|
|cellular response to metal ion|
|response to ketone|
|cellular response to decreased oxygen levels|
|cellular response to acid chemical|
|cofactor biosynthetic process|
|cellular response to toxic substance|
|response to nutrient|
|cellular response to oxygen levels|
|antigen processing and presentation|
|cellular response to inorganic substance|
|response to alcohol|
|cellular response to nutrient levels|
|cellular response to oxidative stress|
|cellular response to extracellular stimulus|
|regulation of angiogenesis|
|response to antibiotic|
|regulation of vasculature development|
|response to steroid hormone|
|cellular response to external stimulus|
|response to hypoxia|
|response to acid chemical|
|response to decreased oxygen levels|
|response to metal ion|
|neuronal cell body|
|response to oxygen levels|
|response to oxidative stress|
|response to peptide hormone|
|cellular response to drug|
|dendrite|
|generation of precursor metabolites and energy|
|cofactor metabolic process|
|positive regulation of cytokine production|
|response to peptide|
|regulation of ion transmembrane transport|
|neutrophil degranulation|
|protein heterodimerization activity|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|response to nutrient levels|
|inflammatory response|
|drug metabolic process|
|neutrophil activation|
|granulocyte activation|
|response to toxic substance|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|response to extracellular stimulus|
|response to inorganic substance|
|regulation of transmembrane transport|
|myeloid leukocyte activation|
|cellular response to organonitrogen compound|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular response to nitrogen compound|
|regulation of cytokine production|
|regulation of ion transport|
|regulated exocytosis|
|enzyme linked receptor protein signaling pathway|
|leukocyte mediated immunity|
|innate immune response|
|exocytosis|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|response to organic cyclic compound|
|leukocyte activation|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|defense response to other organism|
|oxidation-reduction process|
|Golgi apparatus|
|response to organonitrogen compound|
|secretion by cell|
|response to drug|
|export from cell|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|secretion|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|transmembrane transport|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|ion transport|
|integral component of plasma membrane|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|homeostatic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of transport|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.94|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.75|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15145
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.72 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYBB Expression in NALM6 Cells: -1.72'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>