======= CYCS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYCS
  * **<color #00a2e8>Official Name</color>**: cytochrome c, somatic
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54205|54205]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P99999|P99999]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYCS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYCS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123970|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cytochrom C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|
|respirasome|
|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|
|mitochondrial electron transport, ubiquinol to cytochrome c|
|protein phosphatase type 2A complex|
|aerobic electron transport chain|
|mitochondrial electron transport, cytochrome c to oxygen|
|protein serine/threonine phosphatase activity|
|mitochondrial intermembrane space|
|aerobic respiration|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|respiratory electron transport chain|
|oxidative phosphorylation|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|heme binding|
|positive regulation of cysteine-type endopeptidase activity|
|cellular respiration|
|positive regulation of endopeptidase activity|
|electron transport chain|
|positive regulation of peptidase activity|
|ATP metabolic process|
|protein dephosphorylation|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|energy derivation by oxidation of organic compounds|
|cellular response to oxidative stress|
|regulation of cysteine-type endopeptidase activity|
|dephosphorylation|
|positive regulation of proteolysis|
|response to oxidative stress|
|mitochondrial inner membrane|
|regulation of endopeptidase activity|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|regulation of peptidase activity|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|regulation of proteolysis|
|positive regulation of hydrolase activity|
|apoptotic process|
|oxidation-reduction process|
|programmed cell death|
|cell death|
|mitochondrion|
|regulation of hydrolase activity|
|phosphorylation|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.71|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.74|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.84|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.87|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|1.88|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.89|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.9|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.9|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.91|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.95|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.97|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.01|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.01|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.04|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|2.04|
|[[:results:exp539|42°C R08 exp539]]|2.1|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.13|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.14|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.14|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.16|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.17|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.21|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.28|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.3|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.3|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.33|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.33|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.34|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.36|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.41|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.55|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.57|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.58|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.58|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.59|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.61|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.65|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.76|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.77|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.82|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.83|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.9|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|3.03|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|3.26|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|3.36|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|3.41|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|3.41|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|3.64|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|3.88|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|4.07|
|[[:results:exp135|MS023 7μM R03 exp135]]|4.41|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|4.57|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|4.8|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|4.9|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|5.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hccs|HCCS]]|0.762|
|[[:human genes:b:bak1|BAK1]]|0.745|
|[[:human genes:a:apaf1|APAF1]]|0.742|
|[[:human genes:c:casp9|CASP9]]|0.728|
|[[:human genes:m:march5|MARCH5]]|0.707|
|[[:human genes:v:vdac2|VDAC2]]|0.667|
|[[:human genes:u:ubqln1|UBQLN1]]|0.628|
|[[:human genes:p:plaa|PLAA]]|0.609|
|[[:human genes:f:faf2|FAF2]]|0.595|
|[[:human genes:d:diablo|DIABLO]]|0.591|
|[[:human genes:d:dohh|DOHH]]|0.588|
|[[:human genes:s:serf2|SERF2]]|0.586|
|[[:human genes:t:triap1|TRIAP1]]|0.581|
|[[:human genes:m:mfn1|MFN1]]|0.573|
|[[:human genes:a:atp5j|ATP5J]]|0.567|
|[[:human genes:h:hspd1|HSPD1]]|0.561|
|[[:human genes:c:crls1|CRLS1]]|0.557|
|[[:human genes:e:eny2|ENY2]]|0.554|
|[[:human genes:h:hars|HARS]]|0.553|
|[[:human genes:g:gfpt1|GFPT1]]|0.539|
|[[:human genes:p:ppa2|PPA2]]|0.534|
|[[:human genes:t:tufm|TUFM]]|0.527|
|[[:human genes:u:uap1|UAP1]]|0.516|
|[[:human genes:g:gabpa|GABPA]]|0.515|
|[[:human genes:b:bap1|BAP1]]|0.513|
|[[:human genes:s:slc25a26|SLC25A26]]|0.511|
|[[:human genes:s:stau1|STAU1]]|0.511|
|[[:human genes:o:opa1|OPA1]]|0.51|
|[[:human genes:r:rptor|RPTOR]]|0.503|
|[[:human genes:g:gmppb|GMPPB]]|0.501|
|[[:human genes:t:timm13|TIMM13]]|0.5|
|[[:human genes:m:metap2|METAP2]]|0.499|
|[[:human genes:d:dap3|DAP3]]|0.498|
|[[:human genes:n:nupl2|NUPL2]]|0.495|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.493|
|[[:human genes:p:pnpt1|PNPT1]]|0.491|
|[[:human genes:r:romo1|ROMO1]]|0.491|
|[[:human genes:m:mrps14|MRPS14]]|0.487|
|[[:human genes:a:atad1|ATAD1]]|0.485|
|[[:human genes:c:csnk2b|CSNK2B]]|0.482|
|[[:human genes:t:thg1l|THG1L]]|0.481|
|[[:human genes:n:nxt1|NXT1]]|0.48|
|[[:human genes:p:pmm2|PMM2]]|0.476|
|[[:human genes:b:brwd1|BRWD1]]|0.475|
|[[:human genes:m:mtor|MTOR]]|0.475|
|[[:human genes:t:taz|TAZ]]|0.473|
|[[:human genes:a:atp5a1|ATP5A1]]|0.471|
|[[:human genes:a:atp5i|ATP5I]]|0.468|
|[[:human genes:a:atp5b|ATP5B]]|0.468|
|[[:human genes:c:cox16|COX16]]|0.467|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.462|
|[[:human genes:m:mrps16|MRPS16]]|0.461|
|[[:human genes:m:mrpl21|MRPL21]]|0.457|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.456|
|[[:human genes:a:atp5d|ATP5D]]|0.456|
|[[:human genes:c:coa5|COA5]]|0.456|
|[[:human genes:f:fastkd5|FASTKD5]]|0.454|
|[[:human genes:m:mrpl47|MRPL47]]|0.454|
|[[:human genes:m:meaf6|MEAF6]]|0.453|
|[[:human genes:g:gfer|GFER]]|0.453|
|[[:human genes:a:atp5f1|ATP5F1]]|0.45|
|[[:human genes:e:eif3f|EIF3F]]|0.449|
|[[:human genes:s:suv420h1|SUV420H1]]|0.449|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.444|
|[[:human genes:a:alg5|ALG5]]|0.443|
|[[:human genes:s:sec61g|SEC61G]]|0.443|
|[[:human genes:m:mrps2|MRPS2]]|0.443|
|[[:human genes:u:ube2k|UBE2K]]|0.442|
|[[:human genes:u:ube2g2|UBE2G2]]|0.442|
|[[:human genes:t:thoc6|THOC6]]|0.44|
|[[:human genes:t:tamm41|TAMM41]]|0.439|
|[[:human genes:b:bcs1l|BCS1L]]|0.437|
|[[:human genes:a:atp5o|ATP5O]]|0.437|
|[[:human genes:r:rnmt|RNMT]]|0.436|
|[[:human genes:d:dhx30|DHX30]]|0.436|
|[[:human genes:m:mrps18a|MRPS18A]]|0.435|
|[[:human genes:n:nsd1|NSD1]]|0.429|
|[[:human genes:r:rpusd4|RPUSD4]]|0.428|
|[[:human genes:m:mrp63|MRP63]]|0.428|
|[[:human genes:m:mtpap|MTPAP]]|0.428|
|[[:human genes:d:dars2|DARS2]]|0.428|
|[[:human genes:f:fech|FECH]]|0.427|
|[[:human genes:s:sec16a|SEC16A]]|0.427|
|[[:human genes:m:mrps6|MRPS6]]|0.427|
|[[:human genes:p:pam16|PAM16]]|0.424|
|[[:human genes:s:srp14|SRP14]]|0.423|
|[[:human genes:l:lsm10|LSM10]]|0.42|
|[[:human genes:s:ssb|SSB]]|0.42|
|[[:human genes:c:cox17|COX17]]|0.42|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.419|
|[[:human genes:k:kctd5|KCTD5]]|0.419|
|[[:human genes:m:mrps9|MRPS9]]|0.418|
|[[:human genes:s:sars2|SARS2]]|0.417|
|[[:human genes:k:kdsr|KDSR]]|0.415|
|[[:human genes:s:selrc1|SELRC1]]|0.414|
|[[:human genes:c:cept1|CEPT1]]|0.414|
|[[:human genes:m:mrps5|MRPS5]]|0.414|
|[[:human genes:u:uqcr10|UQCR10]]|0.414|
|[[:human genes:w:wdr24|WDR24]]|0.413|
|[[:human genes:p:prkrir|PRKRIR]]|0.412|
|[[:human genes:c:cox7b|COX7B]]|0.412|
|[[:human genes:d:dhps|DHPS]]|0.411|
|[[:human genes:d:dpagt1|DPAGT1]]|0.411|
|[[:human genes:p:pisd|PISD]]|0.411|
|[[:human genes:r:rpe|RPE]]|0.411|
|[[:human genes:a:atxn10|ATXN10]]|0.41|
|[[:human genes:m:mios|MIOS]]|0.409|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.409|
|[[:human genes:g:gfm1|GFM1]]|0.408|
|[[:human genes:p:pgm3|PGM3]]|0.407|
|[[:human genes:a:atp5c1|ATP5C1]]|0.407|
|[[:human genes:d:ddhd2|DDHD2]]|0.404|
|[[:human genes:a:atp5l|ATP5L]]|0.404|
|[[:human genes:m:mrpl23|MRPL23]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 383/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|17/28|
|blood|17/28|
|bone|10/26|
|breast|23/33|
|central nervous system|17/56|
|cervix|4/4|
|colorectal|11/17|
|esophagus|10/13|
|fibroblast|0/1|
|gastric|9/16|
|kidney|10/21|
|liver|11/20|
|lung|43/75|
|lymphocyte|8/16|
|ovary|10/26|
|pancreas|17/24|
|peripheral nervous system|8/16|
|plasma cell|10/15|
|prostate|0/1|
|skin|15/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|7/22|
|urinary tract|13/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 555
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYCS Expression in NALM6 Cells: 7.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>