======= CYP4A11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYP4A11
  * **<color #00a2e8>Official Name</color>**: cytochrome P450 family 4 subfamily A member 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1579|1579]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q02928|Q02928]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYP4A11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYP4A11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601310|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). {ECO:0000269|PubMed:15611369, ECO:0000269|PubMed:1739747, ECO:0000269|PubMed:7679927}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|p450|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pressure natriuresis|
|leukotriene-B4 20-monooxygenase activity|
|leukotriene catabolic process|
|leukotriene B4 metabolic process|
|leukotriene B4 catabolic process|
|alkane 1-monooxygenase activity|
|icosanoid catabolic process|
|long-chain fatty acid catabolic process|
|omega-hydroxylase P450 pathway|
|fatty acid derivative catabolic process|
|renal system process involved in regulation of blood volume|
|arachidonic acid epoxygenase activity|
|positive regulation of icosanoid secretion|
|positive regulation of fatty acid transport|
|regulation of icosanoid secretion|
|epoxygenase P450 pathway|
|renal system process involved in regulation of systemic arterial blood pressure|
|regulation of fatty acid transport|
|leukotriene metabolic process|
|sodium ion homeostasis|
|positive regulation of organic acid transport|
|renal water homeostasis|
|positive regulation of anion transport|
|arachidonic acid metabolic process|
|regulation of organic acid transport|
|positive regulation of lipid transport|
|multicellular organismal water homeostasis|
|water homeostasis|
|organic hydroxy compound catabolic process|
|positive regulation of lipid localization|
|fatty acid catabolic process|
|regulation of systemic arterial blood pressure|
|regulation of anion transport|
|unsaturated fatty acid metabolic process|
|regulation of lipid transport|
|renal system process|
|icosanoid metabolic process|
|long-chain fatty acid metabolic process|
|monocarboxylic acid catabolic process|
|iron ion binding|
|regulation of lipid localization|
|monovalent inorganic cation homeostasis|
|heme binding|
|fatty acid derivative metabolic process|
|regulation of blood pressure|
|cellular lipid catabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|positive regulation of ion transport|
|lipid catabolic process|
|apical plasma membrane|
|fatty acid metabolic process|
|multicellular organismal homeostasis|
|blood circulation|
|circulatory system process|
|regulation of lipid metabolic process|
|positive regulation of secretion|
|small molecule catabolic process|
|organic hydroxy compound metabolic process|
|regulation of body fluid levels|
|monocarboxylic acid metabolic process|
|metal ion homeostasis|
|intracellular membrane-bounded organelle|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|ion homeostasis|
|regulation of secretion|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxidation-reduction process|
|positive regulation of transport|
|oxoacid metabolic process|
|organic acid metabolic process|
|chemical homeostasis|
|lipid metabolic process|
|homeostatic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11696
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYP4A11 Expression in NALM6 Cells: 0.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>