======= CYP4F12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYP4F12
  * **<color #00a2e8>Official Name</color>**: cytochrome P450 family 4 subfamily F member 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=66002|66002]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HCS2|Q9HCS2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYP4F12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYP4F12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611485|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|p450|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pressure natriuresis|
|vitamin E metabolic process|
|leukotriene B4 catabolic process|
|leukotriene-B4 20-monooxygenase activity|
|leukotriene B4 metabolic process|
|leukotriene catabolic process|
|alkane 1-monooxygenase activity|
|icosanoid catabolic process|
|long-chain fatty acid catabolic process|
|fatty acid derivative catabolic process|
|aromatase activity|
|arachidonic acid epoxygenase activity|
|renal system process involved in regulation of blood volume|
|epoxygenase P450 pathway|
|renal system process involved in regulation of systemic arterial blood pressure|
|very long-chain fatty acid metabolic process|
|leukotriene metabolic process|
|sodium ion homeostasis|
|renal water homeostasis|
|fat-soluble vitamin metabolic process|
|arachidonic acid metabolic process|
|multicellular organismal water homeostasis|
|water homeostasis|
|organic hydroxy compound catabolic process|
|fatty acid catabolic process|
|regulation of systemic arterial blood pressure|
|unsaturated fatty acid metabolic process|
|renal system process|
|icosanoid metabolic process|
|long-chain fatty acid metabolic process|
|monocarboxylic acid catabolic process|
|vitamin metabolic process|
|iron ion binding|
|monovalent inorganic cation homeostasis|
|heme binding|
|fatty acid derivative metabolic process|
|regulation of blood pressure|
|cellular lipid catabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|lipid catabolic process|
|apical plasma membrane|
|fatty acid metabolic process|
|multicellular organismal homeostasis|
|blood circulation|
|circulatory system process|
|small molecule catabolic process|
|organic hydroxy compound metabolic process|
|regulation of body fluid levels|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|metal ion homeostasis|
|intracellular membrane-bounded organelle|
|cation homeostasis|
|inorganic ion homeostasis|
|ion homeostasis|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|chemical homeostasis|
|lipid metabolic process|
|homeostatic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.16|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3058
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYP4F12 Expression in NALM6 Cells: 0.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>