======= CYP4F2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYP4F2
  * **<color #00a2e8>Official Name</color>**: cytochrome P450 family 4 subfamily F member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8529|8529]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78329|P78329]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYP4F2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYP4F2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604426|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|p450|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tocotrienol omega-hydroxylase activity|
|alpha-tocopherol omega-hydroxylase activity|
|menaquinone catabolic process|
|vitamin K catabolic process|
|arachidonic acid omega-hydroxylase activity|
|phylloquinone metabolic process|
|quinone catabolic process|
|phylloquinone catabolic process|
|menaquinone metabolic process|
|pressure natriuresis|
|negative regulation of icosanoid secretion|
|alkane 1-monooxygenase activity|
|leukotriene-B4 20-monooxygenase activity|
|leukotriene B4 metabolic process|
|leukotriene catabolic process|
|leukotriene B4 catabolic process|
|vitamin E metabolic process|
|icosanoid catabolic process|
|vitamin K metabolic process|
|negative regulation of fatty acid transport|
|ketone catabolic process|
|fat-soluble vitamin catabolic process|
|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|
|long-chain fatty acid catabolic process|
|omega-hydroxylase P450 pathway|
|fatty acid derivative catabolic process|
|vitamin catabolic process|
|renal system process involved in regulation of blood volume|
|coenzyme catabolic process|
|arachidonic acid epoxygenase activity|
|positive regulation of icosanoid secretion|
|positive regulation of fatty acid transport|
|regulation of icosanoid secretion|
|negative regulation of organic acid transport|
|epoxygenase P450 pathway|
|renal system process involved in regulation of systemic arterial blood pressure|
|negative regulation of lipid transport|
|regulation of fatty acid transport|
|negative regulation of anion transport|
|very long-chain fatty acid metabolic process|
|leukotriene metabolic process|
|quinone metabolic process|
|sodium ion homeostasis|
|positive regulation of organic acid transport|
|renal water homeostasis|
|fat-soluble vitamin metabolic process|
|negative regulation of lipid localization|
|positive regulation of anion transport|
|arachidonic acid metabolic process|
|regulation of organic acid transport|
|positive regulation of lipid transport|
|cofactor catabolic process|
|multicellular organismal water homeostasis|
|cellular ketone metabolic process|
|water homeostasis|
|organic hydroxy compound catabolic process|
|positive regulation of lipid localization|
|regulation of systemic arterial blood pressure|
|fatty acid catabolic process|
|regulation of anion transport|
|unsaturated fatty acid metabolic process|
|regulation of lipid transport|
|renal system process|
|icosanoid metabolic process|
|long-chain fatty acid metabolic process|
|monocarboxylic acid catabolic process|
|vitamin metabolic process|
|iron ion binding|
|regulation of lipid localization|
|monovalent inorganic cation homeostasis|
|heme binding|
|negative regulation of ion transport|
|fatty acid derivative metabolic process|
|regulation of blood pressure|
|cellular lipid catabolic process|
|negative regulation of secretion|
|coenzyme metabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|positive regulation of ion transport|
|blood coagulation|
|coagulation|
|hemostasis|
|lipid catabolic process|
|apical plasma membrane|
|fatty acid metabolic process|
|multicellular organismal homeostasis|
|blood circulation|
|circulatory system process|
|positive regulation of secretion|
|small molecule catabolic process|
|cofactor metabolic process|
|organic hydroxy compound metabolic process|
|wound healing|
|negative regulation of transport|
|regulation of body fluid levels|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|response to wounding|
|metal ion homeostasis|
|intracellular membrane-bounded organelle|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|ion homeostasis|
|regulation of secretion|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxidation-reduction process|
|positive regulation of transport|
|oxoacid metabolic process|
|organic acid metabolic process|
|chemical homeostasis|
|lipid metabolic process|
|homeostatic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3878
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYP4F2 Expression in NALM6 Cells: -0.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>