======= CYP7B1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYP7B1
  * **<color #00a2e8>Official Name</color>**: cytochrome P450 family 7 subfamily B member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9420|9420]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75881|O75881]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYP7B1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYP7B1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603711|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis. Mutations in this gene have been associated with hereditary spastic paraplegia (SPG5 or HSP), an autosomal recessive disorder. [provided by RefSeq, Apr 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Oxysterol 7alpha-hydroxylase that mediates formation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) from 25- hydroxycholesterol (PubMed:10588945). Plays a key role in cell positioning and movement in lymphoid tissues: 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC) acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (By similarity). {ECO:0000250|UniProtKB:Q60991, ECO:0000269|PubMed:10588945}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|p450|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|oxysterol 7-alpha-hydroxylase activity|
|B cell chemotaxis|
|negative regulation of intracellular estrogen receptor signaling pathway|
|prostate gland epithelium morphogenesis|
|prostate gland morphogenesis|
|bile acid biosynthetic process|
|negative regulation of intracellular steroid hormone receptor signaling pathway|
|bile acid metabolic process|
|prostate gland development|
|regulation of intracellular estrogen receptor signaling pathway|
|lymphocyte chemotaxis|
|lymphocyte migration|
|regulation of intracellular steroid hormone receptor signaling pathway|
|cholesterol homeostasis|
|sterol homeostasis|
|gland morphogenesis|
|cholesterol metabolic process|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|iron ion binding|
|lipid homeostasis|
|sterol metabolic process|
|heme binding|
|leukocyte chemotaxis|
|organic hydroxy compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|positive regulation of epithelial cell proliferation|
|cell chemotaxis|
|steroid metabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|alcohol metabolic process|
|urogenital system development|
|regulation of epithelial cell proliferation|
|leukocyte migration|
|gland development|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|organic hydroxy compound metabolic process|
|monocarboxylic acid metabolic process|
|chemotaxis|
|taxis|
|tissue morphogenesis|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|developmental process involved in reproduction|
|carboxylic acid metabolic process|
|positive regulation of cell population proliferation|
|endoplasmic reticulum membrane|
|animal organ morphogenesis|
|cell migration|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|localization of cell|
|cell motility|
|chemical homeostasis|
|epithelium development|
|lipid metabolic process|
|negative regulation of signal transduction|
|organic cyclic compound biosynthetic process|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|movement of cell or subcellular component|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|small molecule metabolic process|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13304
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYP7B1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>