======= CYR61 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCN1
  * **<color #00a2e8>Official Name</color>**: cellular communication network factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3491|3491]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00622|O00622]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYR61&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYR61|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602369|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. {ECO:0000269|PubMed:11584015}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IGFBP|
|Cys knot|
|TSP 1|
|VWC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intussusceptive angiogenesis|
|apoptotic process involved in heart morphogenesis|
|chondroblast differentiation|
|chorio-allantoic fusion|
|positive regulation of ceramide biosynthetic process|
|positive regulation of osteoblast proliferation|
|positive regulation of sphingolipid biosynthetic process|
|regulation of sphingolipid biosynthetic process|
|apoptotic process involved in morphogenesis|
|atrial septum morphogenesis|
|regulation of ceramide biosynthetic process|
|regulation of membrane lipid metabolic process|
|labyrinthine layer blood vessel development|
|insulin-like growth factor binding|
|labyrinthine layer morphogenesis|
|atrial septum development|
|regulation of osteoblast proliferation|
|atrioventricular valve morphogenesis|
|epiboly involved in wound healing|
|wound healing, spreading of cells|
|embryonic placenta morphogenesis|
|epiboly|
|atrioventricular valve development|
|apoptotic process involved in development|
|extracellular matrix binding|
|placenta blood vessel development|
|cardiac atrium morphogenesis|
|positive regulation of BMP signaling pathway|
|positive regulation of cartilage development|
|cardiac atrium development|
|positive regulation of bone mineralization|
|labyrinthine layer development|
|positive regulation of biomineral tissue development|
|positive regulation of biomineralization|
|morphogenesis of an epithelial sheet|
|heart valve morphogenesis|
|positive regulation of osteoblast differentiation|
|positive regulation of phospholipase activity|
|heart valve development|
|regulation of cartilage development|
|positive regulation of lipase activity|
|regulation of phospholipase activity|
|ventricular septum development|
|cardiac septum morphogenesis|
|regulation of bone mineralization|
|positive regulation of lipid biosynthetic process|
|positive regulation of ossification|
|embryonic placenta development|
|regulation of BMP signaling pathway|
|regulation of biomineral tissue development|
|regulation of biomineralization|
|regulation of lipase activity|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cardiac septum development|
|reactive oxygen species metabolic process|
|regulation of osteoblast differentiation|
|positive regulation of cell-substrate adhesion|
|osteoblast differentiation|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|integrin binding|
|extracellular matrix structural constituent|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of lipid metabolic process|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of cellular amide metabolic process|
|placenta development|
|heparin binding|
|cardiac chamber development|
|cartilage development|
|positive regulation of endopeptidase activity|
|regulation of lipid biosynthetic process|
|regulation of ossification|
|positive regulation of peptidase activity|
|regulation of cell-substrate adhesion|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|connective tissue development|
|extracellular matrix|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cysteine-type endopeptidase activity|
|heart morphogenesis|
|ossification|
|regulation of cellular response to growth factor stimulus|
|regulation of ERK1 and ERK2 cascade|
|endoplasmic reticulum lumen|
|angiogenesis|
|extracellular matrix organization|
|positive regulation of proteolysis|
|post-translational protein modification|
|collagen-containing extracellular matrix|
|in utero embryonic development|
|extracellular structure organization|
|regulation of lipid metabolic process|
|positive regulation of cell adhesion|
|regulation of cellular amide metabolic process|
|blood vessel morphogenesis|
|regulation of endopeptidase activity|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|regulation of peptidase activity|
|wound healing|
|blood vessel development|
|skeletal system development|
|positive regulation of cell migration|
|cell-cell adhesion|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|heart development|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|positive regulation of kinase activity|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|developmental process involved in reproduction|
|regulation of cell adhesion|
|positive regulation of cell death|
|regulation of proteolysis|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|regulation of protein kinase activity|
|tube development|
|regulation of cell migration|
|circulatory system development|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|apoptotic process|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|programmed cell death|
|positive regulation of phosphorylation|
|cell motility|
|localization of cell|
|cell death|
|epithelium development|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|locomotion|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12024
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYR61 Expression in NALM6 Cells: -3.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>