======= CYTH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYTH1
  * **<color #00a2e8>Official Name</color>**: cytohesin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9267|9267]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15438|Q15438]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYTH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYTH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182115|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity). {ECO:0000250|UniProtKB:Q9QX11, ECO:0000269|PubMed:10652308, ECO:0000269|PubMed:9653114}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
|Sec7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ARF guanyl-nucleotide exchange factor activity|
|regulation of ARF protein signal transduction|
|establishment of epithelial cell polarity|
|extrinsic component of cytoplasmic side of plasma membrane|
|adherens junction|
|establishment of cell polarity|
|bicellular tight junction|
|lipid binding|
|establishment or maintenance of cell polarity|
|regulation of Ras protein signal transduction|
|regulation of small GTPase mediated signal transduction|
|Golgi membrane|
|regulation of cell adhesion|
|regulation of intracellular signal transduction|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-2.02|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.94|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.86|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.78|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.75|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.74|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-1.7|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.7|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|1.76|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13776
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYTH1 Expression in NALM6 Cells: 4.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>