======= DAB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DAB2
  * **<color #00a2e8>Official Name</color>**: DAB adaptor protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1601|1601]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P98082|P98082]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DAB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DAB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601236|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor- mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin- mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr- 419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PID|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|leading edge cell differentiation|
|positive regulation of clathrin-dependent endocytosis|
|positive regulation of early endosome to late endosome transport|
|positive regulation of Wnt signaling pathway, planar cell polarity pathway|
|clathrin adaptor activity|
|positive regulation of SMAD protein signal transduction|
|positive regulation of cytoplasmic transport|
|positive regulation of non-canonical Wnt signaling pathway|
|cargo receptor activity|
|negative regulation of androgen receptor signaling pathway|
|regulation of Wnt signaling pathway, planar cell polarity pathway|
|regulation of clathrin-dependent endocytosis|
|regulation of early endosome to late endosome transport|
|negative regulation of protein localization to plasma membrane|
|regulation of SMAD protein signal transduction|
|regulation of non-canonical Wnt signaling pathway|
|regulation of cytoplasmic transport|
|negative regulation of protein localization to cell periphery|
|regulation of androgen receptor signaling pathway|
|positive regulation of cellular response to transforming growth factor beta stimulus|
|positive regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of protein localization to membrane|
|negative regulation of intracellular steroid hormone receptor signaling pathway|
|positive regulation of epithelial to mesenchymal transition|
|positive regulation of pathway-restricted SMAD protein phosphorylation|
|SMAD binding|
|positive regulation of receptor-mediated endocytosis|
|clathrin-coated vesicle membrane|
|clathrin-coated pit|
|clathrin-coated vesicle|
|regulation of pathway-restricted SMAD protein phosphorylation|
|regulation of intracellular steroid hormone receptor signaling pathway|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of epithelial to mesenchymal transition|
|integrin-mediated signaling pathway|
|regulation of protein localization to plasma membrane|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of endocytosis|
|regulation of receptor-mediated endocytosis|
|negative regulation of protein binding|
|positive regulation of proteasomal protein catabolic process|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of establishment of planar polarity|
|negative regulation of cellular protein localization|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of protein localization to cell periphery|
|regulation of cellular response to transforming growth factor beta stimulus|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|fibrillar center|
|positive regulation of cellular protein catabolic process|
|regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of binding|
|negative regulation of canonical Wnt signaling pathway|
|positive regulation of Wnt signaling pathway|
|regulation of morphogenesis of an epithelium|
|regulation of proteasomal protein catabolic process|
|regulation of protein localization to membrane|
|protein C-terminus binding|
|regulation of endocytosis|
|positive regulation of intracellular transport|
|negative regulation of Wnt signaling pathway|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of protein binding|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|receptor-mediated endocytosis|
|regulation of cellular protein catabolic process|
|regulation of animal organ morphogenesis|
|regulation of cellular response to growth factor stimulus|
|regulation of canonical Wnt signaling pathway|
|lysosomal membrane|
|regulation of intracellular transport|
|positive regulation of proteolysis|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|positive regulation of cellular catabolic process|
|regulation of binding|
|regulation of protein catabolic process|
|focal adhesion|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|positive regulation of catabolic process|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|endocytosis|
|import into cell|
|epithelial cell differentiation|
|intracellular membrane-bounded organelle|
|regulation of proteolysis|
|regulation of cellular catabolic process|
|regulation of cell migration|
|membrane organization|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|regulation of cellular localization|
|apoptotic process|
|positive regulation of cell differentiation|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|regulation of catabolic process|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|programmed cell death|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell death|
|epithelium development|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|protein transport|
|negative regulation of cellular biosynthetic process|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|amide transport|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|nitrogen compound transport|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9778
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DAB2 Expression in NALM6 Cells: -1.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>