======= DAB2IP =======
== Gene Information ==
* **Official Symbol**: DAB2IP
* **Official Name**: DAB2 interacting protein
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=153090|153090]]
* **UniProt**: [[https://www.uniprot.org/uniprot/Q5VWQ8|Q5VWQ8]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=DAB2IP&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DAB2IP|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/609205|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: N/A
* **UniProt Summary**: Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to proinflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Mediates also TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6) and Ras. Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5- bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Functions also as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. {ECO:0000269|PubMed:12813029, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:18292600, ECO:0000269|PubMed:19033661, ECO:0000269|PubMed:19903888, ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:20080667, ECO:0000269|PubMed:20154697, ECO:0000269|PubMed:21700930, ECO:0000269|PubMed:22696229}.
|RasGAP|
|C2|
|DUF3498|
|parallel fiber|
|vascular endothelial growth factor receptor-2 signaling pathway|
|climbing fiber|
|AIP1-IRE1 complex|
|negative regulation of phosphatidylinositol 3-kinase activity|
|negative regulation of lipid kinase activity|
|Toll-like receptor 4 binding|
|cerebellar mossy fiber|
|positive regulation of IRE1-mediated unfolded protein response|
|cell motility involved in cerebral cortex radial glia guided migration|
|reelin-mediated signaling pathway|
|vascular endothelial growth factor receptor 2 binding|
|regulation of protein heterodimerization activity|
|endothelial cell apoptotic process|
|negative regulation of vascular endothelial growth factor signaling pathway|
|negative regulation of phospholipid metabolic process|
|negative regulation of toll-like receptor 4 signaling pathway|
|positive regulation of synapse maturation|
|negative regulation of cellular response to vascular endothelial growth factor stimulus|
|phosphatidylinositol 3-kinase regulatory subunit binding|
|activation of MAPKKK activity|
|signaling adaptor activity|
|I-kappaB phosphorylation|
|layer formation in cerebral cortex|
|regulation of IRE1-mediated unfolded protein response|
|negative regulation of vascular endothelial growth factor receptor signaling pathway|
|mitogen-activated protein kinase kinase binding|
|positive regulation of endoplasmic reticulum unfolded protein response|
|negative regulation of phosphatidylinositol 3-kinase signaling|
|regulation of synapse maturation|
|death receptor binding|
|positive regulation of neuron migration|
|regulation of vascular endothelial growth factor signaling pathway|
|regulation of cellular response to vascular endothelial growth factor stimulus|
|mitogen-activated protein kinase kinase kinase binding|
|regulation of toll-like receptor 4 signaling pathway|
|phosphatidylinositol 3-kinase binding|
|cerebral cortex radial glia guided migration|
|telencephalon glial cell migration|
|regulation of endoplasmic reticulum unfolded protein response|
|neuronal cell body membrane|
|negative regulation of epithelial to mesenchymal transition|
|epithelial cell apoptotic process|
|14-3-3 protein binding|
|cerebral cortex radially oriented cell migration|
|negative regulation of fibroblast proliferation|
|phosphatidylinositol-4-phosphate binding|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|protein phosphatase 2A binding|
|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|
|extrinsic apoptotic signaling pathway via death domain receptors|
|glial cell migration|
|positive regulation of response to endoplasmic reticulum stress|
|negative regulation of G0 to G1 transition|
|activation of JUN kinase activity|
|negative regulation of toll-like receptor signaling pathway|
|cellular response to vascular endothelial growth factor stimulus|
|phosphatidylinositol-3-phosphate binding|
|regulation of p38MAPK cascade|
|regulation of neuron migration|
|cellular response to epidermal growth factor stimulus|
|regulation of G0 to G1 transition|
|negative regulation of I-kappaB kinase/NF-kappaB signaling|
|cerebral cortex cell migration|
|negative regulation of GTPase activity|
|negative regulation of epidermal growth factor receptor signaling pathway|
|response to epidermal growth factor|
|negative regulation of endothelial cell migration|
|negative regulation of ERBB signaling pathway|
|negative regulation of Ras protein signal transduction|
|regulation of phosphatidylinositol 3-kinase activity|
|endocytic vesicle|
|telencephalon cell migration|
|negative regulation of small GTPase mediated signal transduction|
|forebrain cell migration|
|regulation of lipid kinase activity|
|negative regulation of ERK1 and ERK2 cascade|
|negative regulation of epithelial cell migration|
|vascular endothelial growth factor receptor signaling pathway|
|regulation of toll-like receptor signaling pathway|
|I-kappaB kinase/NF-kappaB signaling|
|positive regulation of JUN kinase activity|
|positive regulation of dendrite development|
|negative regulation of MAP kinase activity|
|positive regulation of cell cycle arrest|
|JNK cascade|
|regulation of fibroblast proliferation|
|negative regulation of lipid metabolic process|
|negative regulation of NF-kappaB transcription factor activity|
|regulation of epithelial to mesenchymal transition|
|regulation of response to endoplasmic reticulum stress|
|regulation of epidermal growth factor receptor signaling pathway|
|regulation of phospholipid metabolic process|
|regulation of JUN kinase activity|
|negative regulation of cellular protein catabolic process|
|regulation of ERBB signaling pathway|
|kinase binding|
|extrinsic apoptotic signaling pathway|
|negative regulation of angiogenesis|
|positive regulation of proteasomal protein catabolic process|
|stress-activated MAPK cascade|
|negative regulation of blood vessel morphogenesis|
|regulation of cell cycle arrest|
|negative regulation of vasculature development|
|cerebral cortex development|
|regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|negative regulation of epithelial cell proliferation|
|cellular response to unfolded protein|
|SH3 domain binding|
|negative regulation of protein serine/threonine kinase activity|
|negative regulation of protein catabolic process|
|positive regulation of JNK cascade|
|positive regulation of cellular protein catabolic process|
|stress-activated protein kinase signaling cascade|
|tube formation|
|negative regulation of cellular response to growth factor stimulus|
|intrinsic apoptotic signaling pathway|
|cellular response to topologically incorrect protein|
|regulation of dendrite development|
|activation of MAPK activity|
|regulation of endothelial cell migration|
|negative regulation of DNA-binding transcription factor activity|
|response to unfolded protein|
|positive regulation of stress-activated MAPK cascade|
|negative regulation of MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|pallium development|
|cellular response to interleukin-1|
|negative regulation of canonical Wnt signaling pathway|
|positive regulation of apoptotic signaling pathway|
|regulation of proteasomal protein catabolic process|
|cellular response to lipopolysaccharide|
|regulation of JNK cascade|
|response to topologically incorrect protein|
|cellular response to molecule of bacterial origin|
|response to interleukin-1|
|negative regulation of Wnt signaling pathway|
|gliogenesis|
|cellular response to biotic stimulus|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of synapse organization|
|regulation of protein binding|
|regulation of epithelial cell migration|
|negative regulation of protein kinase activity|
|regulation of synapse structure or activity|
|regulation of stress-activated MAPK cascade|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of stress-activated protein kinase signaling cascade|
|cellular response to tumor necrosis factor|
|regulation of Ras protein signal transduction|
|negative regulation of kinase activity|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|response to endoplasmic reticulum stress|
|telencephalon development|
|negative regulation of cell migration|
|positive regulation of MAP kinase activity|
|response to tumor necrosis factor|
|protein-containing complex binding|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell motility|
|negative regulation of transferase activity|
|positive regulation of neuron projection development|
|GTPase activator activity|
|regulation of canonical Wnt signaling pathway|
|apoptotic signaling pathway|
|positive regulation of cell cycle process|
|regulation of angiogenesis|
|regulation of ERK1 and ERK2 cascade|
|axon|
|negative regulation of cellular component movement|
|negative regulation of catabolic process|
|cadherin binding|
|response to lipopolysaccharide|
|angiogenesis|
|regulation of vasculature development|
|negative regulation of locomotion|
|negative regulation of cell cycle process|
|response to molecule of bacterial origin|
|activation of protein kinase activity|
|regulation of epithelial cell proliferation|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of small GTPase mediated signal transduction|
|positive regulation of proteolysis|
|regulation of Wnt signaling pathway|
|positive regulation of cellular catabolic process|
|positive regulation of neuron differentiation|
|MAPK cascade|
|neuronal cell body|
|positive regulation of cell cycle|
|regulation of binding|
|positive regulation of cell projection organization|
|regulation of protein catabolic process|
|forebrain development|
|signal transduction by protein phosphorylation|
|regulation of lipid metabolic process|
|regulation of apoptotic signaling pathway|
|negative regulation of protein phosphorylation|
|blood vessel morphogenesis|
|positive regulation of GTPase activity|
|dendrite|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of protein complex assembly|
|regulation of innate immune response|
|negative regulation of hydrolase activity|
|protein kinase binding|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|cell projection morphogenesis|
|regulation of neuron projection development|
|inflammatory response|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|negative regulation of intracellular signal transduction|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|cell part morphogenesis|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|cellular protein catabolic process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|tube morphogenesis|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|neuron projection development|
|regulation of growth|
|negative regulation of cell population proliferation|
|protein catabolic process|
|response to bacterium|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of proteolysis|
|regulation of cellular response to stress|
|brain development|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|regulation of defense response|
|innate immune response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|head development|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|tube development|
|regulation of cell migration|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|regulation of kinase activity|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|cellular macromolecule catabolic process|
|regulation of cell motility|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|defense response to other organism|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|localization of cell|
|cell motility|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|cell cycle|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
\\
=== CRISPR Data ===
No hits were found.
No correlation found to any other genes in chemogenomics.
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 5204
* **Expression level (log2 read counts)**: 1.81
{{:chemogenomics:nalm6 dist.png?nolink |}}