======= DACH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DACH1
  * **<color #00a2e8>Official Name</color>**: dachshund family transcription factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1602|1602]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UI36|Q9UI36]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DACH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DACH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603803|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ski Sno|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cell proliferation involved in contact inhibition|
|contact inhibition|
|negative regulation of transcription by competitive promoter binding|
|suckling behavior|
|regulation of nuclear cell cycle DNA replication|
|negative regulation of fibroblast proliferation|
|negative regulation of DNA biosynthetic process|
|respiratory gaseous exchange by respiratory system|
|regulation of DNA-dependent DNA replication|
|multi-organism behavior|
|regulation of fibroblast proliferation|
|feeding behavior|
|development of primary female sexual characteristics|
|female sex differentiation|
|regulation of DNA replication|
|regulation of DNA biosynthetic process|
|negative regulation of DNA metabolic process|
|transcription factor complex|
|development of primary sexual characteristics|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|negative regulation of cell migration|
|sex differentiation|
|negative regulation of cell motility|
|negative regulation of cellular component movement|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|negative regulation of locomotion|
|regulation of DNA metabolic process|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cell population proliferation|
|behavior|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|regulation of cell cycle process|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|regulation of cell motility|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of cell population proliferation|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|1.74|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6470
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.38 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DACH1 Expression in NALM6 Cells: -2.38'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>