======= DAGLA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DAGLA
  * **<color #00a2e8>Official Name</color>**: diacylglycerol lipase alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=747|747]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y4D2|Q9Y4D2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DAGLA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DAGLA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614015|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses. {ECO:0000269|PubMed:14610053}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lipase 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endocannabinoid signaling pathway|
|retrograde trans-synaptic signaling by lipid|
|retrograde trans-synaptic signaling by endocannabinoid|
|diacylglycerol catabolic process|
|cannabinoid signaling pathway|
|trans-synaptic signaling by endocannabinoid|
|trans-synaptic signaling by lipid|
|retrograde trans-synaptic signaling|
|varicosity|
|G protein-coupled glutamate receptor signaling pathway|
|diacylglycerol metabolic process|
|neuroblast proliferation|
|neutral lipid catabolic process|
|acylglycerol catabolic process|
|neurotransmitter biosynthetic process|
|glutamate receptor signaling pathway|
|integral component of postsynaptic membrane|
|stem cell proliferation|
|glycerolipid catabolic process|
|arachidonic acid metabolic process|
|neural precursor cell proliferation|
|hydrolase activity|
|neurotransmitter metabolic process|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|unsaturated fatty acid metabolic process|
|icosanoid metabolic process|
|long-chain fatty acid metabolic process|
|fatty acid derivative metabolic process|
|cellular lipid catabolic process|
|postsynaptic membrane|
|lipid catabolic process|
|fatty acid metabolic process|
|regulation of neurotransmitter levels|
|glycerolipid metabolic process|
|trans-synaptic signaling|
|synaptic signaling|
|monocarboxylic acid metabolic process|
|cell population proliferation|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|cell-cell signaling|
|lipid metabolic process|
|G protein-coupled receptor signaling pathway|
|generation of neurons|
|neurogenesis|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-1.71|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.73|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6277
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DAGLA Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>