======= DAZ4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DAZ4
  * **<color #00a2e8>Official Name</color>**: deleted in azoospermia 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57135|57135]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86SG3|Q86SG3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DAZ4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DAZ4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/400048|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|translation activator activity|
|3-UTR-mediated mRNA stabilization|
|positive regulation of translational initiation|
|mRNA stabilization|
|RNA stabilization|
|negative regulation of mRNA catabolic process|
|negative regulation of RNA catabolic process|
|mRNA 3-UTR binding|
|negative regulation of mRNA metabolic process|
|regulation of translational initiation|
|positive regulation of translation|
|positive regulation of cellular amide metabolic process|
|regulation of mRNA stability|
|regulation of RNA stability|
|regulation of mRNA catabolic process|
|negative regulation of cellular catabolic process|
|germ cell development|
|negative regulation of catabolic process|
|regulation of mRNA metabolic process|
|regulation of translation|
|cellular process involved in reproduction in multicellular organism|
|regulation of cellular amide metabolic process|
|posttranscriptional regulation of gene expression|
|spermatogenesis|
|male gamete generation|
|protein-containing complex|
|developmental process involved in reproduction|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|multi-organism reproductive process|
|regulation of catabolic process|
|negative regulation of RNA metabolic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|positive regulation of cellular protein metabolic process|
|cell development|
|positive regulation of protein metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.537|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7789
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DAZ4 Expression in NALM6 Cells: 2.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>