======= DAZAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DAZAP1
  * **<color #00a2e8>Official Name</color>**: DAZ associated protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26528|26528]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96EP5|Q96EP5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DAZAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DAZAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607430|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  RNA-binding protein, which may be required during spermatogenesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|poly(G) binding|
|positive regulation of mRNA splicing, via spliceosome|
|RNA stem-loop binding|
|poly(U) RNA binding|
|positive regulation of mRNA processing|
|positive regulation of RNA splicing|
|maternal placenta development|
|maternal process involved in female pregnancy|
|mRNA 3-UTR binding|
|positive regulation of mRNA metabolic process|
|regulation of mRNA splicing, via spliceosome|
|regulation of RNA splicing|
|regulation of mRNA processing|
|placenta development|
|ribonucleoprotein complex|
|female pregnancy|
|multi-multicellular organism process|
|germ cell development|
|regulation of mRNA metabolic process|
|cellular process involved in reproduction in multicellular organism|
|reproductive structure development|
|reproductive system development|
|spermatogenesis|
|cell population proliferation|
|male gamete generation|
|protein-containing complex|
|developmental process involved in reproduction|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|RNA binding|
|reproductive process|
|reproduction|
|cell development|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.28|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.1|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.93|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.87|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.8|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.76|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.73|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.82|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.86|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.93|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.94|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.94|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.98|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.02|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|2.09|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.14|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.29|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.35|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.36|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.41|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.68|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.74|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.9|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.96|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.97|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|3.03|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|3.07|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|3.11|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|3.25|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|3.27|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|3.28|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|3.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:klf16|KLF16]]|0.418|
|[[:human genes:f:fkbpl|FKBPL]]|0.416|
|[[:human genes:c:c9orf78|C9orf78]]|0.416|
|[[:human genes:c:cbll1|CBLL1]]|0.415|
|[[:human genes:p:ppih|PPIH]]|0.413|
|[[:human genes:p:prr14l|PRR14L]]|0.412|
|[[:human genes:c:ccnk|CCNK]]|0.411|
|[[:human genes:u:ube2h|UBE2H]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2489
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DAZAP1 Expression in NALM6 Cells: 8.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>