======= DAZL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DAZL
  * **<color #00a2e8>Official Name</color>**: deleted in azoospermia like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1618|1618]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92904|Q92904]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DAZL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DAZL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601486|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|female meiosis II|
|meiosis II cell cycle process|
|meiosis II|
|translation activator activity|
|positive regulation of meiotic nuclear division|
|3-UTR-mediated mRNA stabilization|
|oocyte maturation|
|positive regulation of meiotic cell cycle|
|positive regulation of translational initiation|
|female meiotic nuclear division|
|regulation of meiotic nuclear division|
|oocyte development|
|mRNA stabilization|
|oocyte differentiation|
|polysome|
|RNA stabilization|
|regulation of meiotic cell cycle|
|negative regulation of mRNA catabolic process|
|negative regulation of RNA catabolic process|
|positive regulation of nuclear division|
|mRNA 3-UTR binding|
|oogenesis|
|positive regulation of reproductive process|
|negative regulation of mRNA metabolic process|
|regulation of translational initiation|
|positive regulation of translation|
|female gamete generation|
|anatomical structure maturation|
|positive regulation of cellular amide metabolic process|
|meiotic nuclear division|
|cell maturation|
|regulation of reproductive process|
|meiotic cell cycle process|
|regulation of mRNA stability|
|regulation of RNA stability|
|regulation of nuclear division|
|regulation of mRNA catabolic process|
|meiotic cell cycle|
|developmental maturation|
|negative regulation of cellular catabolic process|
|germ cell development|
|nuclear division|
|positive regulation of cell cycle process|
|negative regulation of catabolic process|
|organelle fission|
|regulation of mRNA metabolic process|
|regulation of translation|
|cellular process involved in reproduction in multicellular organism|
|positive regulation of cell cycle|
|regulation of cellular amide metabolic process|
|posttranscriptional regulation of gene expression|
|spermatogenesis|
|male gamete generation|
|protein-containing complex|
|positive regulation of organelle organization|
|developmental process involved in reproduction|
|gamete generation|
|regulation of cell cycle process|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|regulation of catabolic process|
|multi-organism reproductive process|
|cell cycle process|
|identical protein binding|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|cell cycle|
|RNA binding|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|positive regulation of cellular protein metabolic process|
|cell development|
|positive regulation of protein metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.89|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.91|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15429
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DAZL Expression in NALM6 Cells: -2.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>