======= DCAF15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DCAF15
  * **<color #00a2e8>Official Name</color>**: DDB1 and CUL4 associated factor 15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=90379|90379]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q66K64|Q66K64]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DCAF15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DCAF15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620109|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in ubiquitination and degradation through a DBB1-CUL4 E3 protein-ubiquitin ligase. {ECO:0000269|PubMed:16949367}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Cul4-RING E3 ubiquitin ligase complex|
|protein-containing complex|
|protein ubiquitination|
|protein modification by small protein conjugation|
|protein modification by small protein conjugation or removal|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-3.2|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-3.07|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-2.92|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-2.89|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-2.62|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-2.62|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-2.53|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.49|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-2.37|
|[[:results:exp16|DABN 2μM R00 exp16]]|-2.28|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.27|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-2.27|
|[[:results:exp340|BN82002 4μM R07 exp340]]|-2.23|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.2|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-2.15|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.13|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.13|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-2.13|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-2.12|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.08|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-2.07|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-2.01|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-2|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.98|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.94|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.93|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.92|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-1.9|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.89|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.89|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.88|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.87|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.87|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.83|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-1.83|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.83|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-1.83|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.81|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.8|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.74|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-1.73|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.7|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.02|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.2|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:asb3|ASB3]]|0.505|
|[[:human genes:u:urm1|URM1]]|0.413|
|[[:human genes:d:dedd|DEDD]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4191
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DCAF15 Expression in NALM6 Cells: 5.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>