======= DCC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DCC
  * **<color #00a2e8>Official Name</color>**: DCC netrin 1 receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1630|1630]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P43146|P43146]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DCC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DCC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/120470|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. {ECO:0000269|PubMed:8187090, ECO:0000269|PubMed:8861902}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|ig|
|Neogenin C|
|fn3|
|V-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spinal cord ventral commissure morphogenesis|
|dorsal/ventral axon guidance|
|regulation of netrin-activated signaling pathway|
|negative regulation of netrin-activated signaling pathway|
|netrin receptor activity|
|anterior/posterior axon guidance|
|negative regulation of collateral sprouting|
|netrin-activated signaling pathway|
|postsynaptic modulation of chemical synaptic transmission|
|regulation of collateral sprouting|
|central nervous system projection neuron axonogenesis|
|negative regulation of dendrite development|
|extrinsic apoptotic signaling pathway in absence of ligand|
|signal transduction in absence of ligand|
|central nervous system neuron axonogenesis|
|integral component of postsynaptic density membrane|
|negative regulation of axonogenesis|
|central nervous system neuron development|
|Schaffer collateral - CA1 synapse|
|extrinsic apoptotic signaling pathway|
|negative regulation of cell morphogenesis involved in differentiation|
|negative regulation of developmental growth|
|spinal cord development|
|regulation of extent of cell growth|
|neuron migration|
|transmembrane signaling receptor activity|
|regulation of dendrite development|
|negative regulation of neuron projection development|
|central nervous system neuron differentiation|
|regulation of cell size|
|negative regulation of cell projection organization|
|negative regulation of cell growth|
|regulation of axonogenesis|
|negative regulation of neuron differentiation|
|negative regulation of growth|
|axon guidance|
|neuron projection guidance|
|apoptotic signaling pathway|
|negative regulation of neurogenesis|
|axon|
|regulation of cell morphogenesis involved in differentiation|
|regulation of neuron death|
|negative regulation of nervous system development|
|regulation of developmental growth|
|negative regulation of cell development|
|axonogenesis|
|regulation of cellular component size|
|axon development|
|regulation of cell growth|
|cell morphogenesis involved in neuron differentiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|cell part morphogenesis|
|regulation of anatomical structure size|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cell migration|
|central nervous system development|
|neuron differentiation|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|cell death|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|generation of neurons|
|movement of cell or subcellular component|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|regulation of cell death|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5674
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DCC Expression in NALM6 Cells: 0.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>