======= DCLRE1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DCLRE1A
  * **<color #00a2e8>Official Name</color>**: DNA cross-link repair 1A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9937|9937]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6PJP8|Q6PJP8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DCLRE1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DCLRE1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609682|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. {ECO:0000269|PubMed:15542852}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DRMBL|
|Lactamase B 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|5-3 exodeoxyribonuclease activity|
|protection from non-homologous end joining at telomere|
|telomere maintenance in response to DNA damage|
|telomere capping|
|interstrand cross-link repair|
|damaged DNA binding|
|double-strand break repair via nonhomologous end joining|
|non-recombinational repair|
|telomere maintenance|
|telomere organization|
|nuclear chromosome, telomeric region|
|fibrillar center|
|double-strand break repair|
|nucleic acid phosphodiester bond hydrolysis|
|anatomical structure homeostasis|
|cell division|
|DNA repair|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|chromosome organization|
|cell cycle|
|homeostatic process|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.07|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-1.92|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16382
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DCLRE1A Expression in NALM6 Cells: 3.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>