======= DCSTAMP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DCSTAMP
  * **<color #00a2e8>Official Name</color>**: dendrocyte expressed seven transmembrane protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81501|81501]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H295|Q9H295]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DCSTAMP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DCSTAMP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605933|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DC STAMP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of macrophage fusion|
|regulation of macrophage fusion|
|osteoclast fusion|
|cellular response to macrophage colony-stimulating factor stimulus|
|response to macrophage colony-stimulating factor|
|multinuclear osteoclast differentiation|
|positive regulation of monocyte differentiation|
|positive regulation of bone resorption|
|positive regulation of bone remodeling|
|regulation of monocyte differentiation|
|myeloid dendritic cell differentiation|
|myeloid dendritic cell activation|
|positive regulation of syncytium formation by plasma membrane fusion|
|cellular response to interleukin-4|
|regulation of syncytium formation by plasma membrane fusion|
|response to interleukin-4|
|positive regulation of tissue remodeling|
|dendritic cell differentiation|
|cell-cell fusion|
|syncytium formation by plasma membrane fusion|
|syncytium formation|
|regulation of bone resorption|
|osteoclast differentiation|
|regulation of bone remodeling|
|positive regulation of myeloid leukocyte differentiation|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|regulation of tissue remodeling|
|positive regulation of myeloid cell differentiation|
|integral component of endoplasmic reticulum membrane|
|myeloid leukocyte differentiation|
|regulation of myeloid leukocyte differentiation|
|membrane fusion|
|positive regulation of leukocyte differentiation|
|negative regulation of cell growth|
|positive regulation of hemopoiesis|
|endosome membrane|
|myeloid cell differentiation|
|regulation of myeloid cell differentiation|
|cellular response to tumor necrosis factor|
|negative regulation of growth|
|response to tumor necrosis factor|
|regulation of leukocyte differentiation|
|leukocyte differentiation|
|regulation of cell growth|
|regulation of hemopoiesis|
|hemopoiesis|
|myeloid leukocyte activation|
|hematopoietic or lymphoid organ development|
|cell surface|
|immune system development|
|regulation of growth|
|membrane organization|
|anatomical structure formation involved in morphogenesis|
|leukocyte activation|
|endoplasmic reticulum membrane|
|positive regulation of cell differentiation|
|cellular response to cytokine stimulus|
|regulation of anatomical structure morphogenesis|
|cell activation|
|response to cytokine|
|positive regulation of immune system process|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.75|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.04|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|3.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7277
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DCSTAMP Expression in NALM6 Cells: -6.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>