======= DCT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DCT
  * **<color #00a2e8>Official Name</color>**: dopachrome tautomerase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1638|1638]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P40126|P40126]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DCT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DCT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191275|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA) (PubMed:8306979). Involved in regulating eumelanin and phaeomelanin levels. {ECO:0000269|PubMed:8306979}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tyrosinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|melanin biosynthetic process from tyrosine|
|ventricular zone neuroblast division|
|dopachrome isomerase activity|
|forebrain ventricular zone progenitor cell division|
|forebrain neuroblast division|
|tyrosine metabolic process|
|melanin biosynthetic process|
|melanin metabolic process|
|melanosome membrane|
|neuroblast division|
|neuronal stem cell division|
|secondary metabolite biosynthetic process|
|positive regulation of neuroblast proliferation|
|somatic stem cell division|
|cell proliferation in forebrain|
|neuroblast proliferation|
|regulation of neuroblast proliferation|
|stem cell division|
|phenol-containing compound biosynthetic process|
|positive regulation of stem cell proliferation|
|aromatic amino acid family metabolic process|
|developmental pigmentation|
|pigment biosynthetic process|
|positive regulation of neural precursor cell proliferation|
|stem cell proliferation|
|secondary metabolic process|
|copper ion binding|
|pigment metabolic process|
|regulation of stem cell proliferation|
|forebrain generation of neurons|
|neural precursor cell proliferation|
|phenol-containing compound metabolic process|
|regulation of neural precursor cell proliferation|
|pigmentation|
|melanosome|
|oxidoreductase activity|
|organic hydroxy compound biosynthetic process|
|alpha-amino acid metabolic process|
|cellular amino acid metabolic process|
|forebrain development|
|epidermis development|
|organic hydroxy compound metabolic process|
|positive regulation of neurogenesis|
|cell division|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell population proliferation|
|brain development|
|head development|
|regulation of neurogenesis|
|carboxylic acid metabolic process|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|oxidation-reduction process|
|positive regulation of cell differentiation|
|central nervous system development|
|oxoacid metabolic process|
|organic acid metabolic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|positive regulation of developmental process|
|generation of neurons|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13663
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DCT Expression in NALM6 Cells: -1.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>