======= DCTN6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DCTN6
  * **<color #00a2e8>Official Name</color>**: dynactin subunit 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10671|10671]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00399|O00399]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DCTN6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DCTN6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612963|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hexapep|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dynactin complex|
|condensed chromosome kinetochore|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|antigen processing and presentation|
|Golgi vesicle transport|
|centrosome|
|intracellular transport|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2.1|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-2.09|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-2.07|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.03|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-1.97|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.94|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.88|
|[[:results:exp302|35°C R06 exp302]]|-1.84|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-1.84|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.79|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-1.79|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.76|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.76|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-1.71|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.71|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|3.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:eprs|EPRS]]|0.51|
|[[:human genes:o:osgep|OSGEP]]|0.486|
|[[:human genes:d:ddx20|DDX20]]|0.485|
|[[:human genes:v:vezt|VEZT]]|0.479|
|[[:human genes:r:rnmt|RNMT]]|0.458|
|[[:human genes:a:atxn10|ATXN10]]|0.456|
|[[:human genes:r:rpp21|RPP21]]|0.453|
|[[:human genes:t:thg1l|THG1L]]|0.449|
|[[:human genes:r:rbm14|RBM14]]|0.446|
|[[:human genes:r:rtcb|RTCB]]|0.445|
|[[:human genes:m:med16|MED16]]|0.444|
|[[:human genes:g:gemin8|GEMIN8]]|0.442|
|[[:human genes:s:snapc5|SNAPC5]]|0.436|
|[[:human genes:a:adsl|ADSL]]|0.434|
|[[:human genes:g:gmppb|GMPPB]]|0.432|
|[[:human genes:a:aars|AARS]]|0.428|
|[[:human genes:v:vrk1|VRK1]]|0.427|
|[[:human genes:t:tbcb|TBCB]]|0.427|
|[[:human genes:a:alg1|ALG1]]|0.427|
|[[:human genes:w:wdr92|WDR92]]|0.425|
|[[:human genes:d:dcp2|DCP2]]|0.422|
|[[:human genes:d:dctn5|DCTN5]]|0.42|
|[[:human genes:p:pmm2|PMM2]]|0.418|
|[[:human genes:d:dpagt1|DPAGT1]]|0.416|
|[[:human genes:t:tbca|TBCA]]|0.414|
|[[:human genes:m:mad2l1|MAD2L1]]|0.41|
|[[:human genes:n:nae1|NAE1]]|0.41|
|[[:human genes:b:bub3|BUB3]]|0.409|
|[[:human genes:t:tsen34|TSEN34]]|0.409|
|[[:human genes:p:pam16|PAM16]]|0.407|
|[[:human genes:p:pelo|PELO]]|0.405|
|[[:human genes:g:gemin6|GEMIN6]]|0.402|
|[[:human genes:g:gnb1l|GNB1L]]|0.401|
|[[:human genes:t:tti2|TTI2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 639/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|26/28|
|blood|16/28|
|bone|23/26|
|breast|31/33|
|central nervous system|51/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|18/21|
|liver|19/20|
|lung|68/75|
|lymphocyte|13/16|
|ovary|23/26|
|pancreas|23/24|
|peripheral nervous system|14/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|18/24|
|soft tissue|7/9|
|thyroid|1/2|
|upper aerodigestive|18/22|
|urinary tract|26/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1278
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DCTN6 Expression in NALM6 Cells: 4.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>