======= DDX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDX1
  * **<color #00a2e8>Official Name</color>**: DEAD-box helicase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1653|1653]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92499|Q92499]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601257|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF- kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). {ECO:0000269|PubMed:12183465, ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:18710941, ECO:0000269|PubMed:20573827, ECO:0000269|PubMed:24870230}. (Microbial infection) Required for Coronavirus IBV replication. {ECO:0000269|PubMed:20573827}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SPRY|
|DEAD|
|Helicase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA/RNA helicase activity|
|cleavage body|
|positive regulation of myeloid dendritic cell cytokine production|
|regulation of myeloid dendritic cell cytokine production|
|positive regulation of dendritic cell cytokine production|
|protein localization to cytoplasmic stress granule|
|tRNA-splicing ligase complex|
|regulation of dendritic cell cytokine production|
|nuclease activity|
|tRNA splicing, via endonucleolytic cleavage and ligation|
|exonuclease activity|
|RNA splicing, via endonucleolytic cleavage and ligation|
|positive regulation of myeloid leukocyte cytokine production involved in immune response|
|poly(A) binding|
|positive regulation of myeloid leukocyte mediated immunity|
|helicase activity|
|response to exogenous dsRNA|
|response to dsRNA|
|positive regulation of cytokine production involved in immune response|
|spliceosomal complex assembly|
|regulation of myeloid leukocyte mediated immunity|
|RNA helicase activity|
|cytoplasmic stress granule|
|double-stranded RNA binding|
|regulation of translational initiation|
|transcription coregulator activity|
|regulation of cytokine production involved in immune response|
|positive regulation of production of molecular mediator of immune response|
|DNA duplex unwinding|
|DNA geometric change|
|tRNA processing|
|positive regulation of leukocyte mediated immunity|
|regulation of production of molecular mediator of immune response|
|ribonucleoprotein complex|
|double-strand break repair|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|tRNA metabolic process|
|defense response to virus|
|regulation of leukocyte mediated immunity|
|positive regulation of immune effector process|
|ribonucleoprotein complex assembly|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|ribonucleoprotein complex subunit organization|
|response to virus|
|DNA conformation change|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|nucleic acid phosphodiester bond hydrolysis|
|RNA splicing, via transesterification reactions|
|regulation of translation|
|ncRNA processing|
|chromatin binding|
|RNA splicing|
|regulation of cellular amide metabolic process|
|positive regulation of cytokine production|
|ribonucleoprotein complex biogenesis|
|regulation of immune effector process|
|ncRNA metabolic process|
|mRNA processing|
|DNA repair|
|posttranscriptional regulation of gene expression|
|regulation of cytokine production|
|mRNA metabolic process|
|protein localization to organelle|
|DNA metabolic process|
|innate immune response|
|cellular response to DNA damage stimulus|
|cellular protein-containing complex assembly|
|positive regulation of immune response|
|RNA processing|
|response to organic cyclic compound|
|defense response to other organism|
|positive regulation of intracellular signal transduction|
|chromosome organization|
|response to nitrogen compound|
|immune effector process|
|positive regulation of immune system process|
|regulation of immune response|
|mitochondrion|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|RNA binding|
|DNA binding|
|ATP binding|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of immune system process|
|positive regulation of signal transduction|
|RNA metabolic process|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|immune response|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.21|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-1.84|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.71|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.71|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.76|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.76|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.87|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.88|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.91|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.94|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.94|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.01|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.14|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.22|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.23|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.66|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.591|
|[[:human genes:p:pyroxd1|PYROXD1]]|0.558|
|[[:human genes:r:rtcb|RTCB]]|0.552|
|[[:human genes:t:tsen34|TSEN34]]|0.55|
|[[:human genes:f:fh|FH]]|0.527|
|[[:human genes:e:elp2|ELP2]]|0.518|
|[[:human genes:a:alg1|ALG1]]|0.506|
|[[:human genes:c:c14orf166|C14orf166]]|0.506|
|[[:human genes:d:dpagt1|DPAGT1]]|0.504|
|[[:human genes:r:rpp21|RPP21]]|0.489|
|[[:human genes:d:dolk|DOLK]]|0.487|
|[[:human genes:e:elp3|ELP3]]|0.486|
|[[:human genes:r:rfk|RFK]]|0.48|
|[[:human genes:t:tsen54|TSEN54]]|0.48|
|[[:human genes:u:uap1|UAP1]]|0.476|
|[[:human genes:v:vezt|VEZT]]|0.474|
|[[:human genes:a:atxn10|ATXN10]]|0.473|
|[[:human genes:u:urm1|URM1]]|0.471|
|[[:human genes:g:gfpt1|GFPT1]]|0.466|
|[[:human genes:d:dnlz|DNLZ]]|0.459|
|[[:human genes:r:rptor|RPTOR]]|0.458|
|[[:human genes:a:alg2|ALG2]]|0.447|
|[[:human genes:a:atic|ATIC]]|0.446|
|[[:human genes:t:trmt5|TRMT5]]|0.442|
|[[:human genes:d:dr1|DR1]]|0.44|
|[[:human genes:p:pmm2|PMM2]]|0.436|
|[[:human genes:d:dohh|DOHH]]|0.436|
|[[:human genes:r:rft1|RFT1]]|0.435|
|[[:human genes:g:gnb1l|GNB1L]]|0.434|
|[[:human genes:p:ppp6c|PPP6C]]|0.433|
|[[:human genes:a:atp5o|ATP5O]]|0.43|
|[[:human genes:o:osgep|OSGEP]]|0.429|
|[[:human genes:f:fam98b|FAM98B]]|0.427|
|[[:human genes:t:tbcb|TBCB]]|0.426|
|[[:human genes:s:snapc5|SNAPC5]]|0.425|
|[[:human genes:t:tti2|TTI2]]|0.424|
|[[:human genes:p:ppp4c|PPP4C]]|0.423|
|[[:human genes:s:srp14|SRP14]]|0.423|
|[[:human genes:t:triap1|TRIAP1]]|0.421|
|[[:human genes:l:lsm11|LSM11]]|0.419|
|[[:human genes:e:eef1e1|EEF1E1]]|0.418|
|[[:human genes:c:c15orf41|C15orf41]]|0.416|
|[[:human genes:g:gemin8|GEMIN8]]|0.416|
|[[:human genes:g:gemin6|GEMIN6]]|0.414|
|[[:human genes:t:tsen15|TSEN15]]|0.413|
|[[:human genes:e:elp6|ELP6]]|0.412|
|[[:human genes:t:tprkb|TPRKB]]|0.412|
|[[:human genes:a:atp5b|ATP5B]]|0.41|
|[[:human genes:n:nae1|NAE1]]|0.409|
|[[:human genes:k:kti12|KTI12]]|0.408|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.407|
|[[:human genes:p:pelo|PELO]]|0.406|
|[[:human genes:w:wdr92|WDR92]]|0.406|
|[[:human genes:c:ctu1|CTU1]]|0.404|
|[[:human genes:p:ppcs|PPCS]]|0.403|
|[[:human genes:e:exoc4|EXOC4]]|0.402|
|[[:human genes:a:atp2b1|ATP2B1]]|0.401|
|[[:human genes:r:rpia|RPIA]]|0.4|
|[[:human genes:f:fnta|FNTA]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 11/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|1/14|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 675
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDX1 Expression in NALM6 Cells: 7.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>