======= DDX21 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDX21
  * **<color #00a2e8>Official Name</color>**: DExD-box helicase 21
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9188|9188]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NR30|Q9NR30]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDX21&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDX21|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606357|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'- O-methylation, possibly by promoting the recruitment of late- acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:9461305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GUCT|
|Helicase C|
|DEAD|
|ResIII|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of myeloid dendritic cell cytokine production|
|regulation of myeloid dendritic cell cytokine production|
|positive regulation of dendritic cell cytokine production|
|7SK snRNA binding|
|regulation of dendritic cell cytokine production|
|snoRNA binding|
|positive regulation of myeloid leukocyte cytokine production involved in immune response|
|miRNA binding|
|positive regulation of myeloid leukocyte mediated immunity|
|rRNA binding|
|response to exogenous dsRNA|
|response to dsRNA|
|positive regulation of cytokine production involved in immune response|
|regulation of myeloid leukocyte mediated immunity|
|positive regulation of gene expression, epigenetic|
|RNA helicase activity|
|double-stranded RNA binding|
|regulation of cytokine production involved in immune response|
|positive regulation of production of molecular mediator of immune response|
|osteoblast differentiation|
|positive regulation of leukocyte mediated immunity|
|regulation of production of molecular mediator of immune response|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|defense response to virus|
|regulation of leukocyte mediated immunity|
|rRNA processing|
|positive regulation of immune effector process|
|rRNA metabolic process|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of gene expression, epigenetic|
|ossification|
|response to virus|
|ribosome biogenesis|
|ncRNA processing|
|positive regulation of cytokine production|
|ribonucleoprotein complex biogenesis|
|regulation of immune effector process|
|ncRNA metabolic process|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|regulation of cytokine production|
|innate immune response|
|nucleolus|
|positive regulation of immune response|
|RNA processing|
|response to organic cyclic compound|
|defense response to other organism|
|positive regulation of intracellular signal transduction|
|identical protein binding|
|response to nitrogen compound|
|immune effector process|
|nucleobase-containing compound biosynthetic process|
|positive regulation of immune system process|
|regulation of immune response|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|RNA binding|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
|positive regulation of gene expression|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-2.67|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-2.38|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-2.29|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2.09|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.02|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.93|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.86|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.82|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.8|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.78|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-1.77|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.76|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.75|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.74|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.71|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|1.91|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.93|
|[[:results:exp303|39°C R06 exp303]]|2.13|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.28|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|2.44|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|2.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:chd4|CHD4]]|0.449|
|[[:human genes:r:rpl35|RPL35]]|0.447|
|[[:human genes:s:smg7|SMG7]]|0.447|
|[[:human genes:r:riok2|RIOK2]]|0.436|
|[[:human genes:c:ctage4|CTAGE4]]|0.429|
|[[:human genes:s:smg1|SMG1]]|0.428|
|[[:human genes:p:psmb2|PSMB2]]|0.424|
|[[:human genes:p:psmd1|PSMD1]]|0.423|
|[[:human genes:p:psmc1|PSMC1]]|0.422|
|[[:human genes:n:nup205|NUP205]]|0.421|
|[[:human genes:p:psma7|PSMA7]]|0.42|
|[[:human genes:p:psmb4|PSMB4]]|0.415|
|[[:human genes:l:lrr1|LRR1]]|0.414|
|[[:human genes:r:rps2|RPS2]]|0.413|
|[[:human genes:t:ticrr|TICRR]]|0.412|
|[[:human genes:p:pan3|PAN3]]|0.41|
|[[:human genes:p:psmd2|PSMD2]]|0.409|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.408|
|[[:human genes:v:vasn|VASN]]|0.407|
|[[:human genes:b:bysl|BYSL]]|0.407|
|[[:human genes:p:pole|POLE]]|0.405|
|[[:human genes:p:pan2|PAN2]]|0.404|
|[[:human genes:b:bage2|BAGE2]]|0.404|
|[[:human genes:b:bage|BAGE]]|0.403|
|[[:human genes:b:bage5|BAGE5]]|0.403|
|[[:human genes:b:bage3|BAGE3]]|0.403|
|[[:human genes:b:bage4|BAGE4]]|0.403|
|[[:human genes:c:cbwd3|CBWD3]]|0.401|
|[[:human genes:p:psmd11|PSMD11]]|0.401|
|[[:human genes:z:zfand5|ZFAND5]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 138/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|5/28|
|blood|1/28|
|bone|3/26|
|breast|4/33|
|central nervous system|7/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|1/13|
|fibroblast|1/1|
|gastric|5/16|
|kidney|7/21|
|liver|3/20|
|lung|10/75|
|lymphocyte|1/16|
|ovary|5/26|
|pancreas|3/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|14/24|
|soft tissue|6/9|
|thyroid|0/2|
|upper aerodigestive|7/22|
|urinary tract|9/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 512
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDX21 Expression in NALM6 Cells: 9.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>