======= DDX23 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDX23
  * **<color #00a2e8>Official Name</color>**: DEAD-box helicase 23
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9416|9416]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BUQ8|Q9BUQ8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDX23&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDX23|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612172|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. {ECO:0000269|PubMed:18425142}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DEAD|
|Helicase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cis assembly of pre-catalytic spliceosome|
|U5 snRNP|
|mRNA cis splicing, via spliceosome|
|helicase activity|
|spliceosomal complex assembly|
|RNA helicase activity|
|catalytic step 2 spliceosome|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|nucleolus|
|RNA processing|
|RNA binding|
|ATP binding|
|protein-containing complex assembly|
|RNA metabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-3.63|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-3.06|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.93|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.84|
|[[:results:exp539|42°C R08 exp539]]|-2.44|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-2.23|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.85|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.84|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.84|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.83|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.81|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.8|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-1.78|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.7|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.78|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.8|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.82|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.11|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|2.17|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nup85|NUP85]]|0.46|
|[[:human genes:m:med17|MED17]]|0.446|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.442|
|[[:human genes:s:supt5h|SUPT5H]]|0.433|
|[[:human genes:t:thrsp|THRSP]]|0.431|
|[[:human genes:r:rad21|RAD21]]|0.415|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.413|
|[[:human genes:n:nup160|NUP160]]|0.411|
|[[:human genes:e:exosc3|EXOSC3]]|0.405|
|[[:human genes:n:nup43|NUP43]]|0.402|
|[[:human genes:s:sec13|SEC13]]|0.401|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 551/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|21/28|
|blood|20/28|
|bone|19/26|
|breast|25/33|
|central nervous system|47/56|
|cervix|3/4|
|colorectal|12/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|12/21|
|liver|15/20|
|lung|56/75|
|lymphocyte|13/16|
|ovary|17/26|
|pancreas|18/24|
|peripheral nervous system|12/16|
|plasma cell|6/15|
|prostate|0/1|
|skin|17/24|
|soft tissue|7/9|
|thyroid|1/2|
|upper aerodigestive|17/22|
|urinary tract|21/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 102
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDX23 Expression in NALM6 Cells: 7.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>