======= DDX46 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDX46
  * **<color #00a2e8>Official Name</color>**: DEAD-box helicase 46
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9879|9879]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7L014|Q7L014]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDX46&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDX46|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617848|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an essential role in splicing, either prior to, or during splicing A complex formation. {ECO:0000269|PubMed:12234937}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Helicase C|
|DEAD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Cajal body|
|RNA helicase activity|
|fibrillar center|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|RNA binding|
|ATP binding|
|RNA metabolic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-2.28|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.27|
|[[:results:exp539|42°C R08 exp539]]|-2.01|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.89|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.7|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.72|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.72|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.74|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.77|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.77|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.79|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.82|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.93|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|2.17|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2.19|
|[[:results:exp73|LJH685 5μM R02 exp73]]|2.29|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|2.35|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|2.52|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.63|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|2.73|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|3.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 12/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 134
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDX46 Expression in NALM6 Cells: 7.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>