======= DDX56 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDX56
  * **<color #00a2e8>Official Name</color>**: DEAD-box helicase 56
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54606|54606]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NY93|Q9NY93]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDX56&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDX56|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608023|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DEAD|
|Helicase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA helicase activity|
|rRNA processing|
|rRNA metabolic process|
|positive regulation of neuron projection development|
|ribosome biogenesis|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|positive regulation of neurogenesis|
|ncRNA metabolic process|
|regulation of neuron projection development|
|positive regulation of nervous system development|
|positive regulation of cell development|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|nucleolus|
|RNA processing|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|RNA binding|
|ATP binding|
|generation of neurons|
|neurogenesis|
|RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.75|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.751|
|[[:human genes:p:psma7|PSMA7]]|0.554|
|[[:human genes:r:rps3a|RPS3A]]|0.537|
|[[:human genes:r:rpl35|RPL35]]|0.52|
|[[:human genes:n:npipb5|NPIPB5]]|0.508|
|[[:human genes:s:supt6h|SUPT6H]]|0.503|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.501|
|[[:human genes:r:rps7|RPS7]]|0.494|
|[[:human genes:c:ccna2|CCNA2]]|0.491|
|[[:human genes:c:cbwd3|CBWD3]]|0.487|
|[[:human genes:p:psmb4|PSMB4]]|0.487|
|[[:human genes:p:psmd2|PSMD2]]|0.484|
|[[:human genes:c:cbwd6|CBWD6]]|0.48|
|[[:human genes:r:rps5|RPS5]]|0.478|
|[[:human genes:c:cdc6|CDC6]]|0.478|
|[[:human genes:d:dtl|DTL]]|0.474|
|[[:human genes:p:pola1|POLA1]]|0.474|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.473|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.472|
|[[:human genes:m:mt1e|MT1E]]|0.472|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.472|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.472|
|[[:human genes:c:cbwd5|CBWD5]]|0.471|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.469|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.468|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.466|
|[[:human genes:c:c14orf93|C14orf93]]|0.464|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.462|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.459|
|[[:human genes:r:rps9|RPS9]]|0.458|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.458|
|[[:human genes:p:pola2|POLA2]]|0.458|
|[[:human genes:t:tsg101|TSG101]]|0.457|
|[[:human genes:p:psmd11|PSMD11]]|0.455|
|[[:human genes:c:ccdc116|CCDC116]]|0.454|
|[[:human genes:s:slc6a17|SLC6A17]]|0.452|
|[[:human genes:n:nop16|NOP16]]|0.452|
|[[:human genes:c:copb2|COPB2]]|0.452|
|[[:human genes:a:adrm1|ADRM1]]|0.451|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.447|
|[[:human genes:d:ddtl|DDTL]]|0.447|
|[[:human genes:r:rad51|RAD51]]|0.447|
|[[:human genes:t:twistnb|TWISTNB]]|0.447|
|[[:human genes:s:ssh2|SSH2]]|0.446|
|[[:human genes:z:znf574|ZNF574]]|0.443|
|[[:human genes:c:copg1|COPG1]]|0.442|
|[[:human genes:l:lrr1|LRR1]]|0.441|
|[[:human genes:n:nup160|NUP160]]|0.44|
|[[:human genes:r:rnf121|RNF121]]|0.438|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.438|
|[[:human genes:n:nol10|NOL10]]|0.437|
|[[:human genes:t:tceb3c|TCEB3C]]|0.436|
|[[:human genes:p:pan3|PAN3]]|0.435|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.434|
|[[:human genes:v:vasn|VASN]]|0.434|
|[[:human genes:p:psma6|PSMA6]]|0.433|
|[[:human genes:r:rps2|RPS2]]|0.432|
|[[:human genes:f:fam160a1|FAM160A1]]|0.43|
|[[:human genes:t:trim52|TRIM52]]|0.429|
|[[:human genes:k:kctd17|KCTD17]]|0.428|
|[[:human genes:a:acsf2|ACSF2]]|0.427|
|[[:human genes:c:ctage4|CTAGE4]]|0.427|
|[[:human genes:p:pole|POLE]]|0.426|
|[[:human genes:l:lad1|LAD1]]|0.426|
|[[:human genes:b:bysl|BYSL]]|0.426|
|[[:human genes:r:rps12|RPS12]]|0.426|
|[[:human genes:r:rpl30|RPL30]]|0.425|
|[[:human genes:t:tspy2|TSPY2]]|0.425|
|[[:human genes:r:rpl15|RPL15]]|0.423|
|[[:human genes:r:rrp15|RRP15]]|0.423|
|[[:human genes:r:rps11|RPS11]]|0.422|
|[[:human genes:a:aatf|AATF]]|0.422|
|[[:human genes:t:timeless|TIMELESS]]|0.421|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.421|
|[[:human genes:s:supt5h|SUPT5H]]|0.42|
|[[:human genes:p:psmb1|PSMB1]]|0.42|
|[[:human genes:c:cebpz|CEBPZ]]|0.419|
|[[:human genes:p:polr2f|POLR2F]]|0.419|
|[[:human genes:p:pbxip1|PBXIP1]]|0.419|
|[[:human genes:c:c19orf53|C19orf53]]|0.419|
|[[:human genes:c:cdc73|CDC73]]|0.418|
|[[:human genes:a:aqr|AQR]]|0.418|
|[[:human genes:i:ints5|INTS5]]|0.416|
|[[:human genes:t:traip|TRAIP]]|0.416|
|[[:human genes:r:rbbp5|RBBP5]]|0.416|
|[[:human genes:r:rps19|RPS19]]|0.415|
|[[:human genes:u:utp3|UTP3]]|0.415|
|[[:human genes:p:psmb2|PSMB2]]|0.415|
|[[:human genes:e:exosc9|EXOSC9]]|0.414|
|[[:human genes:m:mdm2|MDM2]]|0.413|
|[[:human genes:p:psmd1|PSMD1]]|0.413|
|[[:human genes:w:wdr3|WDR3]]|0.412|
|[[:human genes:r:rpl14|RPL14]]|0.412|
|[[:human genes:a:ankle2|ANKLE2]]|0.411|
|[[:human genes:e:elmod3|ELMOD3]]|0.411|
|[[:human genes:c:cdt1|CDT1]]|0.411|
|[[:human genes:t:tuba8|TUBA8]]|0.41|
|[[:human genes:o:orc1|ORC1]]|0.409|
|[[:human genes:z:znf583|ZNF583]]|0.409|
|[[:human genes:n:nip7|NIP7]]|0.408|
|[[:human genes:n:nbpf10|NBPF10]]|0.406|
|[[:human genes:g:golga8j|GOLGA8J]]|0.406|
|[[:human genes:z:zfand5|ZFAND5]]|0.406|
|[[:human genes:i:ik|IK]]|0.406|
|[[:human genes:n:nup54|NUP54]]|0.405|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.404|
|[[:human genes:t:tspy1|TSPY1]]|0.404|
|[[:human genes:t:tspy8|TSPY8]]|0.404|
|[[:human genes:n:nupl1|NUPL1]]|0.404|
|[[:human genes:p:psmd3|PSMD3]]|0.403|
|[[:human genes:r:rpl32|RPL32]]|0.403|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.403|
|[[:human genes:i:il2rb|IL2RB]]|0.402|
|[[:human genes:n:npipb8|NPIPB8]]|0.402|
|[[:human genes:c:chd4|CHD4]]|0.402|
|[[:human genes:s:snrpa1|SNRPA1]]|0.402|
|[[:human genes:g:gga3|GGA3]]|0.401|
|[[:human genes:s:scaf1|SCAF1]]|0.4|
|[[:human genes:r:rad21|RAD21]]|0.4|
|[[:human genes:g:golga8o|GOLGA8O]]|0.4|
|[[:human genes:b:brd2|BRD2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 335
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDX56 Expression in NALM6 Cells: 6.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>