======= DEK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DEK
  * **<color #00a2e8>Official Name</color>**: DEK proto-oncogene
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7913|7913]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35659|P35659]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DEK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DEK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/125264|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in chromatin organization. {ECO:0000269|PubMed:17524367}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAP|
|DEK C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|viral genome replication|
|positive regulation of gene expression, epigenetic|
|regulation of double-strand break repair|
|regulation of DNA repair|
|histone binding|
|viral life cycle|
|regulation of response to DNA damage stimulus|
|regulation of gene expression, epigenetic|
|regulation of DNA metabolic process|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|chromatin organization|
|viral process|
|regulation of cellular response to stress|
|symbiotic process|
|interspecies interaction between organisms|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|DNA binding|
|regulation of response to stress|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.26|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.8|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.72|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.13|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hdac8|HDAC8]]|0.499|
|[[:human genes:m:med13l|MED13L]]|0.473|
|[[:human genes:a:atxn7l3|ATXN7L3]]|0.427|
|[[:human genes:p:prkar1a|PRKAR1A]]|0.423|
|[[:human genes:c:csnk2a1|CSNK2A1]]|0.413|
|[[:human genes:s:scaf8|SCAF8]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2443
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DEK Expression in NALM6 Cells: 8.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>