======= DENND4A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DENND4A
  * **<color #00a2e8>Official Name</color>**: DENN domain containing 4A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10260|10260]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z401|Q7Z401]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DENND4A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DENND4A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600382|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DENN|
|dDENN|
|uDENN|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Rab guanyl-nucleotide exchange factor activity|
|DNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-3.15|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.17|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.93|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-1.87|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.87|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.7|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.75|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.82|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.93|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.96|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.98|
|[[:results:exp210|LB-100 2μM R05 exp210]]|2|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.11|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.17|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.23|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.36|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.83|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|3.21|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rab10|RAB10]]|0.5|
|[[:human genes:r:rabif|RABIF]]|0.496|
|[[:human genes:c:cmtm6|CMTM6]]|0.445|
|[[:human genes:u:ube2g2|UBE2G2]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2790
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DENND4A Expression in NALM6 Cells: 6.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>