======= DGAT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DGAT1
  * **<color #00a2e8>Official Name</color>**: diacylglycerol O-acyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8694|8694]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75907|O75907]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DGAT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DGAT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604900|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. {ECO:0000269|PubMed:16214399, ECO:0000269|PubMed:9756920}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MBOAT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retinol O-fatty-acyltransferase activity|
|diacylglycerol O-acyltransferase activity|
|2-acylglycerol O-acyltransferase activity|
|acylglycerol acyl-chain remodeling|
|very-low-density lipoprotein particle assembly|
|fatty acid homeostasis|
|triglyceride biosynthetic process|
|diacylglycerol metabolic process|
|neutral lipid biosynthetic process|
|acylglycerol biosynthetic process|
|transferase activity, transferring acyl groups|
|long-chain fatty-acyl-CoA metabolic process|
|plasma lipoprotein particle assembly|
|lipid storage|
|protein-lipid complex assembly|
|retinol metabolic process|
|fatty-acyl-CoA metabolic process|
|plasma lipoprotein particle organization|
|protein-lipid complex subunit organization|
|anion homeostasis|
|regulation of plasma lipoprotein particle levels|
|triglyceride metabolic process|
|primary alcohol metabolic process|
|specific granule membrane|
|thioester metabolic process|
|acyl-CoA metabolic process|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|retinoid metabolic process|
|diterpenoid metabolic process|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|nucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|lipid homeostasis|
|isoprenoid metabolic process|
|maintenance of location|
|fatty acid derivative metabolic process|
|hormone metabolic process|
|glycerolipid biosynthetic process|
|coenzyme metabolic process|
|purine ribonucleotide metabolic process|
|alcohol metabolic process|
|lipid localization|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|glycerolipid metabolic process|
|extracellular structure organization|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic hydroxy compound metabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of hormone levels|
|nucleobase-containing small molecule metabolic process|
|lipid biosynthetic process|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|ion homeostasis|
|cellular amide metabolic process|
|exocytosis|
|organophosphate metabolic process|
|leukocyte activation|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|secretion by cell|
|carbohydrate derivative metabolic process|
|export from cell|
|cell activation|
|immune effector process|
|chemical homeostasis|
|secretion|
|lipid metabolic process|
|protein-containing complex assembly|
|homeostatic process|
|small molecule metabolic process|
|protein-containing complex subunit organization|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.34|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-2|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.99|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.83|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.75|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.73|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.73|
|[[:results:exp433|LJH685 50μM R08 exp433]]|1.7|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.74|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.79|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.97|
|[[:results:exp224|CB-839 10μM R05 exp224]]|2.02|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.13|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|2.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12677
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DGAT1 Expression in NALM6 Cells: 4.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>