======= DGKI =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DGKI
  * **<color #00a2e8>Official Name</color>**: diacylglycerol kinase iota
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9162|9162]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75912|O75912]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DGKI&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DGKI|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604072|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank 2|
|DAGK cat|
|C1 1|
|DAGK acc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extrinsic component of presynaptic active zone membrane|
|habituation|
|extrinsic component of postsynaptic density membrane|
|nonassociative learning|
|guanyl-nucleotide exchange factor complex|
|diacylglycerol kinase activity|
|Ras GTPase binding|
|regulation of long-term synaptic depression|
|GTPase inhibitor activity|
|NAD+ kinase activity|
|diacylglycerol metabolic process|
|protein kinase C-activating G protein-coupled receptor signaling pathway|
|excitatory synapse|
|negative regulation of GTPase activity|
|axon terminus|
|excitatory postsynaptic potential|
|positive regulation of Ras protein signal transduction|
|lipid phosphorylation|
|chemical synaptic transmission, postsynaptic|
|regulation of synaptic transmission, glutamatergic|
|positive regulation of small GTPase mediated signal transduction|
|regulation of synaptic vesicle exocytosis|
|Schaffer collateral - CA1 synapse|
|acylglycerol metabolic process|
|regulation of postsynaptic membrane potential|
|neutral lipid metabolic process|
|neurotransmitter secretion|
|signal release from synapse|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|synaptic vesicle|
|platelet activation|
|regulation of neurotransmitter transport|
|learning|
|dendritic spine|
|regulation of regulated secretory pathway|
|signal release|
|neurotransmitter transport|
|regulation of synaptic plasticity|
|lipid modification|
|regulation of exocytosis|
|regulation of Ras protein signal transduction|
|learning or memory|
|synapse|
|blood coagulation|
|coagulation|
|hemostasis|
|cognition|
|regulation of small GTPase mediated signal transduction|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|neuronal cell body|
|glycerolipid metabolic process|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|negative regulation of hydrolase activity|
|synaptic signaling|
|wound healing|
|regulation of GTPase activity|
|regulation of body fluid levels|
|regulation of vesicle-mediated transport|
|response to wounding|
|behavior|
|protein-containing complex|
|perinuclear region of cytoplasm|
|regulation of secretion by cell|
|negative regulation of catalytic activity|
|regulation of secretion|
|regulation of cellular localization|
|cellular lipid metabolic process|
|secretion by cell|
|positive regulation of intracellular signal transduction|
|export from cell|
|cell activation|
|cell-cell signaling|
|secretion|
|negative regulation of molecular function|
|lipid metabolic process|
|regulation of hydrolase activity|
|phosphorylation|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|ATP binding|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-1.81|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10858
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DGKI Expression in NALM6 Cells: -1.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>