======= DHCR24 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DHCR24
  * **<color #00a2e8>Official Name</color>**: 24-dehydrocholesterol reductase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1718|1718]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15392|Q15392]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DHCR24&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DHCR24|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606418|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis. {ECO:0000269|PubMed:11007892, ECO:0000269|PubMed:11519011, ECO:0000269|PubMed:22010141}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FAD binding 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|delta24(24-1) sterol reductase activity|
|delta24-sterol reductase activity|
|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor|
|cholesterol biosynthetic process via desmosterol|
|cholesterol biosynthetic process via lathosterol|
|plasminogen activation|
|amyloid precursor protein catabolic process|
|amyloid precursor protein metabolic process|
|male genitalia development|
|peptide antigen binding|
|FAD binding|
|zymogen activation|
|cholesterol biosynthetic process|
|secondary alcohol biosynthetic process|
|genitalia development|
|sterol biosynthetic process|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of cysteine-type endopeptidase activity|
|alcohol biosynthetic process|
|cholesterol metabolic process|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|sterol metabolic process|
|cell cycle arrest|
|male sex differentiation|
|protein processing|
|organic hydroxy compound biosynthetic process|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|protein maturation|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|Ras protein signal transduction|
|negative regulation of peptidase activity|
|steroid metabolic process|
|sex differentiation|
|regulation of neuron death|
|alcohol metabolic process|
|small GTPase mediated signal transduction|
|enzyme binding|
|negative regulation of proteolysis|
|cytoskeleton|
|skin development|
|response to oxidative stress|
|regulation of endopeptidase activity|
|reproductive structure development|
|reproductive system development|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|organic hydroxy compound metabolic process|
|negative regulation of cell cycle|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|Golgi membrane|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|membrane organization|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|apoptotic process|
|endoplasmic reticulum membrane|
|oxidation-reduction process|
|negative regulation of cell death|
|cell cycle process|
|endoplasmic reticulum|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cell death|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|lipid metabolic process|
|proteolysis|
|regulation of hydrolase activity|
|organic cyclic compound biosynthetic process|
|cell cycle|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|regulation of cell death|
|intracellular signal transduction|
|small molecule metabolic process|
|tissue development|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.12|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.97|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.72|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11015
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DHCR24 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>