======= DHX35 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DHX35
  * **<color #00a2e8>Official Name</color>**: DEAH-box helicase 35
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=60625|60625]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H5Z1|Q9H5Z1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DHX35&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DHX35|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621401|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in pre-mRNA splicing.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|OB NTP bind|
|HA2|
|Helicase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|3-5 RNA helicase activity|
|catalytic step 2 spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|in utero embryonic development|
|RNA splicing|
|mRNA processing|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|mRNA metabolic process|
|RNA processing|
|embryo development|
|RNA binding|
|ATP binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.7|
|[[:results:exp461|BS-181 20μM R08 exp461]]|1.7|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.74|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.84|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.87|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.93|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.98|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.02|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.07|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.1|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.25|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.37|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:w:wdr83|WDR83]]|0.61|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1113
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DHX35 Expression in NALM6 Cells: 4.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>