======= DIABLO =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DIABLO
  * **<color #00a2e8>Official Name</color>**: diablo IAP-binding mitochondrial protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56616|56616]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NR28|Q9NR28]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DIABLO&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DIABLO|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605219|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis- inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance. {ECO:0000269|PubMed:10929711, ECO:0000269|PubMed:14523016, ECO:0000269|PubMed:15200957}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Smac DIABLO|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|
|CD40 receptor complex|
|intrinsic apoptotic signaling pathway in response to oxidative stress|
|cell death in response to oxidative stress|
|extrinsic apoptotic signaling pathway via death domain receptors|
|neuron apoptotic process|
|neuron death|
|cytoplasmic side of plasma membrane|
|mitochondrial intermembrane space|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|extrinsic apoptotic signaling pathway|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|intrinsic apoptotic signaling pathway|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of endopeptidase activity|
|positive regulation of peptidase activity|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|cellular response to oxidative stress|
|regulation of cysteine-type endopeptidase activity|
|apoptotic signaling pathway|
|positive regulation of proteolysis|
|response to oxidative stress|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|regulation of proteolysis|
|positive regulation of hydrolase activity|
|apoptotic process|
|programmed cell death|
|cell death|
|mitochondrion|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.71|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.72|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|1.81|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|1.86|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|1.89|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.91|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.08|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.08|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.1|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.11|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.18|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.26|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.3|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.36|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.37|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.37|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.43|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.48|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.48|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.61|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.72|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.9|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|3.2|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|3.7|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|3.84|
|[[:results:exp135|MS023 7μM R03 exp135]]|3.84|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|3.88|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|4.3|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|4.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:apaf1|APAF1]]|0.691|
|[[:human genes:c:casp9|CASP9]]|0.661|
|[[:human genes:b:bak1|BAK1]]|0.651|
|[[:human genes:m:march5|MARCH5]]|0.646|
|[[:human genes:p:plaa|PLAA]]|0.634|
|[[:human genes:v:vdac2|VDAC2]]|0.627|
|[[:human genes:u:ubqln1|UBQLN1]]|0.595|
|[[:human genes:c:cycs|CYCS]]|0.591|
|[[:human genes:h:hars|HARS]]|0.59|
|[[:human genes:a:atad1|ATAD1]]|0.565|
|[[:human genes:m:meaf6|MEAF6]]|0.559|
|[[:human genes:h:hccs|HCCS]]|0.555|
|[[:human genes:h:hspd1|HSPD1]]|0.551|
|[[:human genes:f:faf2|FAF2]]|0.549|
|[[:human genes:s:serf2|SERF2]]|0.542|
|[[:human genes:g:gabpa|GABPA]]|0.539|
|[[:human genes:s:stau1|STAU1]]|0.52|
|[[:human genes:d:dohh|DOHH]]|0.516|
|[[:human genes:a:atp5j|ATP5J]]|0.515|
|[[:human genes:m:mfn1|MFN1]]|0.513|
|[[:human genes:b:bap1|BAP1]]|0.511|
|[[:human genes:e:eny2|ENY2]]|0.505|
|[[:human genes:n:nxt1|NXT1]]|0.475|
|[[:human genes:r:rptor|RPTOR]]|0.469|
|[[:human genes:c:csnk2b|CSNK2B]]|0.466|
|[[:human genes:m:metap2|METAP2]]|0.462|
|[[:human genes:m:mtor|MTOR]]|0.459|
|[[:human genes:d:ddhd2|DDHD2]]|0.448|
|[[:human genes:u:ube2k|UBE2K]]|0.445|
|[[:human genes:g:gfpt1|GFPT1]]|0.439|
|[[:human genes:r:rtcb|RTCB]]|0.43|
|[[:human genes:r:rad23b|RAD23B]]|0.429|
|[[:human genes:r:rpn1|RPN1]]|0.427|
|[[:human genes:t:triap1|TRIAP1]]|0.426|
|[[:human genes:n:nsd1|NSD1]]|0.426|
|[[:human genes:u:ube2g2|UBE2G2]]|0.425|
|[[:human genes:u:uap1|UAP1]]|0.425|
|[[:human genes:w:wdr24|WDR24]]|0.424|
|[[:human genes:o:opa1|OPA1]]|0.42|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.418|
|[[:human genes:t:tp53|TP53]]|0.412|
|[[:human genes:s:srrd|SRRD]]|0.409|
|[[:human genes:c:crls1|CRLS1]]|0.409|
|[[:human genes:r:romo1|ROMO1]]|0.403|
|[[:human genes:f:fbxo11|FBXO11]]|0.401|
|[[:human genes:m:mios|MIOS]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7405
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DIABLO Expression in NALM6 Cells: 5.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>