======= DICER1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DICER1
  * **<color #00a2e8>Official Name</color>**: dicer 1, ribonuclease III
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23405|23405]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UPY3|Q9UPY3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DICER1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DICER1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606241|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA- induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. {ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:19219043}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|dsRNA bind|
|ResIII|
|PAZ|
|DEAD|
|Helicase C|
|Ribonuclease 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|conversion of ds siRNA to ss siRNA involved in RNA interference|
|ARC complex|
|conversion of ds siRNA to ss siRNA|
|positive regulation of Schwann cell differentiation|
|peripheral nervous system myelin formation|
|regulation of Schwann cell differentiation|
|targeting of mRNA for destruction involved in RNA interference|
|siRNA loading onto RISC involved in RNA interference|
|ribonuclease III activity|
|deoxyribonuclease I activity|
|negative regulation of Schwann cell proliferation|
|regulation of Schwann cell proliferation|
|pre-miRNA binding|
|miRNA loading onto RISC involved in gene silencing by miRNA|
|RISC-loading complex|
|small RNA loading onto RISC|
|production of siRNA involved in RNA interference|
|siRNA binding|
|pre-miRNA processing|
|negative regulation of glial cell proliferation|
|apoptotic DNA fragmentation|
|RISC complex|
|positive regulation of myelination|
|RNA interference|
|myelin assembly|
|miRNA metabolic process|
|DNA catabolic process, endonucleolytic|
|apoptotic nuclear changes|
|peripheral nervous system axon ensheathment|
|myelination in peripheral nervous system|
|cellular component disassembly involved in execution phase of apoptosis|
|endoribonuclease activity|
|production of miRNAs involved in gene silencing by miRNA|
|Schwann cell development|
|DNA catabolic process|
|regulation of glial cell proliferation|
|dsRNA processing|
|production of small RNA involved in gene silencing by RNA|
|helicase activity|
|Schwann cell differentiation|
|negative regulation of gliogenesis|
|regulation of myelination|
|positive regulation of glial cell differentiation|
|gene silencing by miRNA|
|execution phase of apoptosis|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|negative regulation of tumor necrosis factor production|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of nervous system process|
|positive regulation of gliogenesis|
|regulation of glial cell differentiation|
|double-stranded RNA binding|
|peripheral nervous system development|
|endoplasmic reticulum-Golgi intermediate compartment|
|nerve development|
|NIK/NF-kappaB signaling|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|gene silencing by RNA|
|cellular component assembly involved in morphogenesis|
|myelination|
|glial cell development|
|axon ensheathment|
|ensheathment of neurons|
|regulation of gliogenesis|
|growth cone|
|regulation of nervous system process|
|tube formation|
|regulation of tumor necrosis factor production|
|gene silencing|
|regulation of tumor necrosis factor superfamily cytokine production|
|RNA phosphodiester bond hydrolysis|
|glial cell differentiation|
|gliogenesis|
|ribonucleoprotein complex assembly|
|regulation of gene expression, epigenetic|
|protein domain specific binding|
|ribonucleoprotein complex subunit organization|
|negative regulation of cytokine production|
|negative regulation of neurogenesis|
|nucleic acid phosphodiester bond hydrolysis|
|negative regulation of nervous system development|
|negative regulation of cell development|
|nucleobase-containing compound catabolic process|
|ncRNA processing|
|cellular component disassembly|
|dendrite|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|positive regulation of neurogenesis|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|posttranscriptional regulation of gene expression|
|positive regulation of nervous system development|
|positive regulation of cell development|
|regulation of system process|
|tube morphogenesis|
|neuron projection development|
|negative regulation of cell population proliferation|
|regulation of cytokine production|
|negative regulation of cell differentiation|
|cell morphogenesis|
|DNA metabolic process|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|cellular protein-containing complex assembly|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|RNA processing|
|anatomical structure formation involved in morphogenesis|
|cellular macromolecule catabolic process|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|neuron differentiation|
|macromolecule catabolic process|
|programmed cell death|
|cell death|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|RNA metabolic process|
|intracellular signal transduction|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-2|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.89|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.74|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.7|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.484|
|[[:human genes:y:yars|YARS]]|0.472|
|[[:human genes:r:rtcb|RTCB]]|0.47|
|[[:human genes:t:thg1l|THG1L]]|0.461|
|[[:human genes:a:adsl|ADSL]]|0.437|
|[[:human genes:m:med16|MED16]]|0.435|
|[[:human genes:g:gmppb|GMPPB]]|0.434|
|[[:human genes:h:hspd1|HSPD1]]|0.434|
|[[:human genes:p:pelo|PELO]]|0.427|
|[[:human genes:r:rnmt|RNMT]]|0.42|
|[[:human genes:r:rpp21|RPP21]]|0.417|
|[[:human genes:r:rptor|RPTOR]]|0.416|
|[[:human genes:e:exoc4|EXOC4]]|0.415|
|[[:human genes:n:nars|NARS]]|0.411|
|[[:human genes:w:wars|WARS]]|0.411|
|[[:human genes:e:exoc3|EXOC3]]|0.411|
|[[:human genes:a:alg2|ALG2]]|0.409|
|[[:human genes:o:oip5|OIP5]]|0.408|
|[[:human genes:a:alg1|ALG1]]|0.405|
|[[:human genes:t:telo2|TELO2]]|0.405|
|[[:human genes:s:spcs3|SPCS3]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 89/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|3/28|
|bone|3/26|
|breast|1/33|
|central nervous system|9/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|1/16|
|kidney|4/21|
|liver|3/20|
|lung|10/75|
|lymphocyte|1/16|
|ovary|2/26|
|pancreas|4/24|
|peripheral nervous system|6/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|0/22|
|urinary tract|5/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1975
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DICER1 Expression in NALM6 Cells: 7.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>