======= DIDO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DIDO1
  * **<color #00a2e8>Official Name</color>**: death inducer-obliterator 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11083|11083]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BTC0|Q9BTC0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DIDO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DIDO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604140|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TFIIS M|
|SPOC|
|PHD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spindle|
|apoptotic signaling pathway|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|apoptotic process|
|programmed cell death|
|cell death|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.01|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.93|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.87|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.81|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.76|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-1.74|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.72|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.592|
|[[:human genes:p:pola2|POLA2]]|0.532|
|[[:human genes:c:cdc6|CDC6]]|0.496|
|[[:human genes:t:tceb3c|TCEB3C]]|0.491|
|[[:human genes:p:psmb4|PSMB4]]|0.487|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.485|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.482|
|[[:human genes:p:polr2j3|POLR2J3]]|0.48|
|[[:human genes:p:paf1|PAF1]]|0.477|
|[[:human genes:s:sf3a1|SF3A1]]|0.475|
|[[:human genes:o:orc1|ORC1]]|0.467|
|[[:human genes:c:ccna2|CCNA2]]|0.466|
|[[:human genes:t:ticrr|TICRR]]|0.465|
|[[:human genes:r:rad51|RAD51]]|0.464|
|[[:human genes:v:vasn|VASN]]|0.461|
|[[:human genes:n:nupl1|NUPL1]]|0.46|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.459|
|[[:human genes:f:fancm|FANCM]]|0.457|
|[[:human genes:r:rpl35|RPL35]]|0.455|
|[[:human genes:c:chaf1a|CHAF1A]]|0.452|
|[[:human genes:p:prpf8|PRPF8]]|0.451|
|[[:human genes:s:smg7|SMG7]]|0.449|
|[[:human genes:k:krt78|KRT78]]|0.445|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.443|
|[[:human genes:c:cdc73|CDC73]]|0.441|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.441|
|[[:human genes:n:nup133|NUP133]]|0.439|
|[[:human genes:o:orc6|ORC6]]|0.438|
|[[:human genes:a:aqr|AQR]]|0.437|
|[[:human genes:a:ankle2|ANKLE2]]|0.436|
|[[:human genes:s:setd1a|SETD1A]]|0.434|
|[[:human genes:a:acsf2|ACSF2]]|0.434|
|[[:human genes:n:nup160|NUP160]]|0.434|
|[[:human genes:n:narfl|NARFL]]|0.434|
|[[:human genes:r:rpl14|RPL14]]|0.433|
|[[:human genes:g:golga8o|GOLGA8O]]|0.432|
|[[:human genes:h:hap1|HAP1]]|0.426|
|[[:human genes:n:nip7|NIP7]]|0.425|
|[[:human genes:r:rpl6|RPL6]]|0.425|
|[[:human genes:e:eif4a3|EIF4A3]]|0.422|
|[[:human genes:r:rpsa|RPSA]]|0.421|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.419|
|[[:human genes:p:pcf11|PCF11]]|0.418|
|[[:human genes:r:rad21|RAD21]]|0.417|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.416|
|[[:human genes:r:rnf113a|RNF113A]]|0.416|
|[[:human genes:t:traip|TRAIP]]|0.415|
|[[:human genes:c:copg1|COPG1]]|0.415|
|[[:human genes:t:twistnb|TWISTNB]]|0.415|
|[[:human genes:b:bod1l1|BOD1L1]]|0.414|
|[[:human genes:c:cactin|CACTIN]]|0.414|
|[[:human genes:t:taf1|TAF1]]|0.414|
|[[:human genes:c:cwc22|CWC22]]|0.413|
|[[:human genes:s:scaf1|SCAF1]]|0.413|
|[[:human genes:r:riok2|RIOK2]]|0.412|
|[[:human genes:i:iscu|ISCU]]|0.411|
|[[:human genes:s:sf3a2|SF3A2]]|0.411|
|[[:human genes:i:igfn1|IGFN1]]|0.41|
|[[:human genes:d:dtl|DTL]]|0.409|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.407|
|[[:human genes:c:chd4|CHD4]]|0.404|
|[[:human genes:u:upf1|UPF1]]|0.404|
|[[:human genes:r:rps5|RPS5]]|0.404|
|[[:human genes:s:supt5h|SUPT5H]]|0.403|
|[[:human genes:i:ints6|INTS6]]|0.402|
|[[:human genes:r:rpa2|RPA2]]|0.402|
|[[:human genes:s:snrpa1|SNRPA1]]|0.401|
|[[:human genes:n:nbpf10|NBPF10]]|0.401|
|[[:human genes:z:znf655|ZNF655]]|0.4|
|[[:human genes:p:psma7|PSMA7]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 9/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 499
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DIDO1 Expression in NALM6 Cells: 7.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>