======= DIEXF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UTP25
  * **<color #00a2e8>Official Name</color>**: UTP25 small subunit processor component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27042|27042]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q68CQ4|Q68CQ4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DIEXF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DIEXF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619663|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates the p53 pathway to control the expansion growth of digestive organs. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1253|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U3 snoRNA binding|
|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|rRNA binding|
|positive regulation of embryonic development|
|small-subunit processome|
|maturation of SSU-rRNA|
|protein destabilization|
|ribosomal small subunit biogenesis|
|regulation of embryonic development|
|rRNA processing|
|rRNA metabolic process|
|regulation of protein stability|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|protein catabolic process|
|nucleolus|
|RNA processing|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|positive regulation of developmental process|
|RNA binding|
|RNA metabolic process|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.84|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.7|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.71|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|1.76|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.79|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.84|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|1.94|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.97|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|2.03|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|2.07|
|[[:results:exp114|A-196 10μM R03 exp114]]|2.09|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.488|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.439|
|[[:human genes:r:rps12|RPS12]]|0.425|
|[[:human genes:p:prim1|PRIM1]]|0.415|
|[[:human genes:e:exosc9|EXOSC9]]|0.414|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.412|
|[[:human genes:t:timeless|TIMELESS]]|0.409|
|[[:human genes:k:kctd17|KCTD17]]|0.408|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.406|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.405|
|[[:human genes:t:tceb3c|TCEB3C]]|0.405|
|[[:human genes:r:rpl35|RPL35]]|0.404|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.403|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.401|
|[[:human genes:n:narfl|NARFL]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 16/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|1/26|
|breast|0/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|1/20|
|lung|4/75|
|lymphocyte|0/16|
|ovary|3/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 484
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DIEXF Expression in NALM6 Cells: 6.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>