======= DISC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DISC1
  * **<color #00a2e8>Official Name</color>**: DISC1 scaffold protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27185|27185]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NRI5|Q9NRI5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DISC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DISC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605210|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pyramidal neuron migration|
|central region of growth cone|
|pyramidal neuron development|
|pyramidal neuron differentiation|
|regulation of synapse maturation|
|protein localization to microtubule organizing center|
|protein localization to centrosome|
|telencephalon glial cell migration|
|cerebral cortex radial glia guided migration|
|positive regulation of neuroblast proliferation|
|mitochondrial calcium ion homeostasis|
|dynein complex|
|cell proliferation in forebrain|
|TOR signaling|
|cerebral cortex radially oriented cell migration|
|forebrain neuron development|
|regulation of neuroblast proliferation|
|protein localization to microtubule cytoskeleton|
|ciliary base|
|glial cell migration|
|protein localization to cytoskeleton|
|positive regulation of stem cell proliferation|
|kinesin binding|
|cerebral cortex cell migration|
|response to electrical stimulus|
|positive regulation of axon extension|
|non-motile cilium assembly|
|intermediate filament cytoskeleton|
|molecular adaptor activity|
|positive regulation of cell-matrix adhesion|
|forebrain neuron differentiation|
|positive regulation of neural precursor cell proliferation|
|kinesin complex|
|telencephalon cell migration|
|forebrain cell migration|
|regulation of stem cell proliferation|
|forebrain generation of neurons|
|regulation of synaptic transmission, glutamatergic|
|cell body|
|regulation of dendritic spine development|
|neural precursor cell proliferation|
|central nervous system neuron development|
|positive regulation of axonogenesis|
|regulation of neural precursor cell proliferation|
|canonical Wnt signaling pathway|
|regulation of axon extension|
|positive regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of protein binding|
|regulation of extent of cell growth|
|regulation of cell-matrix adhesion|
|cerebral cortex development|
|synaptic vesicle|
|neuron migration|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of cell-substrate adhesion|
|ciliary basal body|
|positive regulation of cellular protein catabolic process|
|regulation of dendrite development|
|regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of cell morphogenesis involved in differentiation|
|positive regulation of cell growth|
|negative regulation of binding|
|positive regulation of developmental growth|
|pallium development|
|positive regulation of Wnt signaling pathway|
|central nervous system neuron differentiation|
|regulation of cell size|
|regulation of axonogenesis|
|postsynaptic membrane|
|regulation of cell-substrate adhesion|
|gliogenesis|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|regulation of synapse organization|
|regulation of protein binding|
|regulation of synapse structure or activity|
|regulation of cellular protein catabolic process|
|postsynaptic density|
|telencephalon development|
|positive regulation of growth|
|protein-containing complex binding|
|positive regulation of neuron projection development|
|regulation of cell morphogenesis involved in differentiation|
|microtubule|
|regulation of developmental growth|
|cilium assembly|
|positive regulation of proteolysis|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|positive regulation of cellular catabolic process|
|positive regulation of neuron differentiation|
|cilium organization|
|regulation of cellular component size|
|regulation of binding|
|positive regulation of cell projection organization|
|regulation of protein catabolic process|
|forebrain development|
|positive regulation of cell adhesion|
|regulation of cell growth|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|positive regulation of catabolic process|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|plasma membrane bounded cell projection assembly|
|calcium ion homeostasis|
|cell projection assembly|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|microtubule cytoskeleton organization|
|regulation of cell morphogenesis|
|divalent inorganic cation homeostasis|
|centrosome|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell junction|
|cell population proliferation|
|cellular metal ion homeostasis|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of neuron differentiation|
|regulation of growth|
|microtubule-based process|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|cation homeostasis|
|regulation of cell projection organization|
|inorganic ion homeostasis|
|regulation of proteolysis|
|protein localization to organelle|
|brain development|
|cellular chemical homeostasis|
|organelle assembly|
|head development|
|ion homeostasis|
|neuron development|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|cellular homeostasis|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|cell migration|
|positive regulation of cell differentiation|
|central nervous system development|
|regulation of catabolic process|
|endoplasmic reticulum|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|chemical homeostasis|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|mitochondrion|
|locomotion|
|positive regulation of developmental process|
|generation of neurons|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16681
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DISC1 Expression in NALM6 Cells: 3.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>