======= DLG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DLG1
  * **<color #00a2e8>Official Name</color>**: discs large MAGUK scaffold protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1739|1739]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12959|Q12959]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DLG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DLG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601014|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known. [provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 2|
|PDZ|
|Guanylate kin|
|PDZ assoc|
|L27 1|
|SH3 1|
|MAGUK N PEST|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|
|structural constituent of postsynaptic density|
|cortical microtubule organization|
|L27 domain binding|
|regulation of membrane repolarization during ventricular cardiac muscle cell action potential|
|maintenance of postsynaptic density structure|
|lateral loop|
|MPP7-DLG1-LIN7 complex|
|regulation of membrane repolarization during cardiac muscle cell action potential|
|maintenance of postsynaptic specialization structure|
|negative regulation of p38MAPK cascade|
|myelin sheath abaxonal region|
|hard palate development|
|astral microtubule organization|
|regulation of potassium ion export across plasma membrane|
|regulation of membrane repolarization during action potential|
|regulation of potassium ion import|
|establishment of centrosome localization|
|guanylate kinase activity|
|GDP metabolic process|
|peristalsis|
|cell projection membrane|
|T cell cytokine production|
|protein localization to postsynaptic specialization membrane|
|neurotransmitter receptor localization to postsynaptic specialization membrane|
|mitogen-activated protein kinase kinase binding|
|immunological synapse formation|
|ionotropic glutamate receptor complex|
|maintenance of synapse structure|
|node of Ranvier|
|GMP metabolic process|
|regulation of ventricular cardiac muscle cell action potential|
|smooth muscle tissue development|
|postsynaptic density organization|
|amyloid precursor protein metabolic process|
|phasic smooth muscle contraction|
|postsynaptic specialization organization|
|membrane raft organization|
|cytokine production involved in immune response|
|regulation of ventricular cardiac muscle cell membrane repolarization|
|postsynaptic density membrane|
|endothelial cell proliferation|
|cellular protein-containing complex localization|
|secondary palate development|
|regulation of protein localization to synapse|
|synaptic membrane|
|regulation of cardiac muscle cell membrane repolarization|
|regulation of cardiac muscle cell action potential|
|centrosome localization|
|microtubule organizing center localization|
|ionotropic glutamate receptor binding|
|protein localization to postsynaptic membrane|
|regulation of membrane repolarization|
|bicellular tight junction assembly|
|regulation of NMDA receptor activity|
|immunological synapse|
|purine ribonucleoside monophosphate metabolic process|
|tight junction assembly|
|regulation of cardiac muscle cell contraction|
|purine nucleoside monophosphate metabolic process|
|tight junction organization|
|potassium channel regulator activity|
|guanosine-containing compound metabolic process|
|regulation of p38MAPK cascade|
|receptor localization to synapse|
|phosphoprotein phosphatase activity|
|T cell mediated immunity|
|regulation of actin filament-based movement|
|regulation of myelination|
|cortical actin cytoskeleton organization|
|branching involved in ureteric bud morphogenesis|
|positive regulation of potassium ion transport|
|negative regulation of stress-activated MAPK cascade|
|apical junction assembly|
|negative regulation of stress-activated protein kinase signaling cascade|
|intercalated disc|
|establishment or maintenance of epithelial cell apical/basal polarity|
|negative regulation of protein kinase B signaling|
|cellular component maintenance|
|receptor clustering|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|cortical cytoskeleton organization|
|molecular adaptor activity|
|establishment or maintenance of apical/basal cell polarity|
|phosphatase binding|
|establishment or maintenance of bipolar cell polarity|
|regulation of action potential|
|ribonucleoside monophosphate metabolic process|
|smooth muscle contraction|
|cytoplasmic microtubule organization|
|ureteric bud morphogenesis|
|cytoplasmic side of plasma membrane|
|mesonephric tubule morphogenesis|
|positive regulation of protein localization to plasma membrane|
|regulation of potassium ion transmembrane transporter activity|
|lateral plasma membrane|
|negative regulation of T cell proliferation|
|purine ribonucleoside metabolic process|
|purine nucleoside diphosphate metabolic process|
|positive regulation of protein localization to cell periphery|
|purine ribonucleoside diphosphate metabolic process|
|regulation of sodium ion transmembrane transport|
|protein localization to synapse|
|purine nucleoside metabolic process|
|nephron tubule morphogenesis|
|ribonucleoside diphosphate metabolic process|
|regulation of glutamate receptor signaling pathway|
|negative regulation of ERK1 and ERK2 cascade|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|renal tubule morphogenesis|
|cell-cell recognition|
|nucleoside monophosphate metabolic process|
|negative regulation of lymphocyte proliferation|
|regulation of neurotransmitter receptor activity|
|negative regulation of mononuclear cell proliferation|
|ribonucleoside metabolic process|
|cytoskeletal protein binding|
|regulation of cardiac muscle contraction|
|nephron tubule development|
|lens development in camera-type eye|
|neuromuscular junction|
|negative regulation of leukocyte proliferation|
|renal tubule development|
|regulation of potassium ion transmembrane transport|
|nucleoside diphosphate metabolic process|
|localization within membrane|
|kidney morphogenesis|
|ureteric bud development|
|epithelial cell proliferation|
|mesonephric tubule development|
|regulation of sodium ion transport|
|mesonephric epithelium development|
|basement membrane|
|postsynapse organization|
|roof of mouth development|
|mesonephros development|
|regulation of striated muscle contraction|
|positive regulation of actin filament polymerization|
|embryonic skeletal system morphogenesis|
|regulation of protein localization to plasma membrane|
|regulation of potassium ion transport|
|nephron epithelium development|
|sarcolemma|
|cell-cell junction assembly|
|nucleoside metabolic process|
|regulation of NIK/NF-kappaB signaling|
|negative regulation of T cell activation|
|regulation of protein localization to cell periphery|
|negative regulation of leukocyte cell-cell adhesion|
|positive regulation of protein localization to membrane|
|bicellular tight junction|
|negative regulation of epithelial cell proliferation|
|nephron development|
|ion channel binding|
|embryonic skeletal system development|
|positive regulation of protein polymerization|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|glycosyl compound metabolic process|
|cell-cell junction organization|
|negative regulation of lymphocyte activation|
|cytokine production|
|regulation of cell shape|
|mitotic cell cycle checkpoint|
|spindle organization|
|regulation of T cell proliferation|
|morphogenesis of a branching epithelium|
|regulation of muscle contraction|
|regulation of actin filament polymerization|
|negative regulation of MAPK cascade|
|morphogenesis of a branching structure|
|cell junction assembly|
|regulation of cation channel activity|
|cell-cell junction|
|regulation of signaling receptor activity|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|production of molecular mediator of immune response|
|regulation of actin polymerization or depolymerization|
|protein localization to plasma membrane|
|regulation of actin filament length|
|protein C-terminus binding|
|regulation of protein localization to membrane|
|cell cycle checkpoint|
|negative regulation of cell activation|
|establishment or maintenance of cell polarity|
|positive regulation of supramolecular fiber organization|
|basolateral plasma membrane|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|protein dephosphorylation|
|cell junction organization|
|regulation of protein kinase B signaling|
|positive regulation of cytoskeleton organization|
|regulation of leukocyte proliferation|
|regulation of protein polymerization|
|membrane raft|
|protein localization to cell periphery|
|regulation of stress-activated MAPK cascade|
|T cell activation|
|regulation of muscle system process|
|regulation of stress-activated protein kinase signaling cascade|
|skeletal system morphogenesis|
|cell recognition|
|actin filament organization|
|regulation of heart contraction|
|positive regulation of protein complex assembly|
|muscle contraction|
|protein-containing complex localization|
|regulation of ion transmembrane transporter activity|
|regulation of actin filament organization|
|regulation of transmembrane transporter activity|
|lymphocyte mediated immunity|
|kidney development|
|synapse organization|
|negative regulation of cell adhesion|
|positive regulation of ion transport|
|regulation of transporter activity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|renal system development|
|regulation of blood circulation|
|embryonic organ morphogenesis|
|regulation of ERK1 and ERK2 cascade|
|regulation of leukocyte cell-cell adhesion|
|muscle tissue development|
|muscle system process|
|epithelial tube morphogenesis|
|negative regulation of mitotic cell cycle|
|dephosphorylation|
|cadherin binding|
|purine ribonucleotide metabolic process|
|camera-type eye development|
|regulation of T cell activation|
|microtubule|
|urogenital system development|
|apical plasma membrane|
|neuron projection|
|positive regulation of cellular protein localization|
|ribonucleotide metabolic process|
|activation of protein kinase activity|
|purine nucleotide metabolic process|
|regulation of epithelial cell proliferation|
|regulation of cation transmembrane transport|
|ribose phosphate metabolic process|
|regulation of actin cytoskeleton organization|
|glutamatergic synapse|
|regulation of supramolecular fiber organization|
|eye development|
|visual system development|
|establishment of organelle localization|
|sensory system development|
|purine-containing compound metabolic process|
|MAPK cascade|
|regulation of cellular component size|
|lymphocyte activation|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|signal transduction by protein phosphorylation|
|regulation of cell-cell adhesion|
|negative regulation of protein phosphorylation|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|reproductive structure development|
|reproductive system development|
|regulation of membrane potential|
|morphogenesis of an epithelium|
|embryonic organ development|
|trans-synaptic signaling|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|synaptic signaling|
|protein kinase binding|
|microtubule cytoskeleton organization|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|skeletal system development|
|cell-cell adhesion|
|negative regulation of intracellular signal transduction|
|regulation of lymphocyte activation|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|positive regulation of protein kinase activity|
|regulation of cellular protein localization|
|nucleobase-containing small molecule metabolic process|
|regulation of cytoskeleton organization|
|sensory organ development|
|cell junction|
|cell population proliferation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|tissue morphogenesis|
|embryonic morphogenesis|
|actin filament-based process|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|organelle localization|
|regulation of system process|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|regulation of leukocyte activation|
|adaptive immune response|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|regulation of cell activation|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|developmental process involved in reproduction|
|microtubule-based process|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|mitotic cell cycle|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|viral process|
|protein localization to organelle|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|leukocyte mediated immunity|
|symbiotic process|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|tube development|
|membrane organization|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|organophosphate metabolic process|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|endoplasmic reticulum membrane|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|regulation of transferase activity|
|embryo development|
|Golgi apparatus|
|positive regulation of transport|
|regulation of cellular component movement|
|cell cycle process|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|carbohydrate derivative metabolic process|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|immune effector process|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|epithelium development|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|phosphorylation|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|small molecule metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.72|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.7|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12075
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DLG1 Expression in NALM6 Cells: 6.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>