======= DLG5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DLG5
  * **<color #00a2e8>Official Name</color>**: discs large MAGUK scaffold protein 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9231|9231]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TDM6|Q8TDM6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DLG5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DLG5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604090|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDZ|
|Guanylate kin|
|DUF622|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|zonula adherens assembly|
|positive regulation of hippo signaling|
|protein localization to adherens junction|
|negative regulation of hippo signaling|
|metanephric collecting duct development|
|apical protein localization|
|collecting duct development|
|regulation of hippo signaling|
|protein localization to cell junction|
|maintenance of cell polarity|
|polarized epithelial cell differentiation|
|receptor signaling complex adaptor activity|
|epithelial tube branching involved in lung morphogenesis|
|positive regulation of smoothened signaling pathway|
|adherens junction assembly|
|positive regulation of dendritic spine development|
|morphogenesis of a polarized epithelium|
|lung morphogenesis|
|apical junction assembly|
|establishment or maintenance of epithelial cell apical/basal polarity|
|establishment or maintenance of bipolar cell polarity|
|establishment or maintenance of apical/basal cell polarity|
|negative regulation of T cell proliferation|
|positive regulation of synapse assembly|
|epithelial to mesenchymal transition|
|positive regulation of dendrite development|
|regulation of dendritic spine development|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|cytoskeletal protein binding|
|regulation of smoothened signaling pathway|
|negative regulation of leukocyte proliferation|
|beta-catenin binding|
|metanephros development|
|adherens junction organization|
|midbrain development|
|cell-cell adherens junction|
|cell-cell junction assembly|
|regulation of synapse assembly|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|branching morphogenesis of an epithelial tube|
|ciliary basal body|
|cell-cell junction organization|
|negative regulation of lymphocyte activation|
|regulation of dendrite development|
|mesenchymal cell differentiation|
|regulation of T cell proliferation|
|morphogenesis of a branching epithelium|
|cell junction assembly|
|morphogenesis of a branching structure|
|lung development|
|respiratory tube development|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|respiratory system development|
|negative regulation of cell activation|
|establishment or maintenance of cell polarity|
|postsynaptic membrane|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|cell junction organization|
|regulation of synapse organization|
|mesenchyme development|
|regulation of leukocyte proliferation|
|regulation of synapse structure or activity|
|postsynaptic density|
|negative regulation of cell migration|
|kidney development|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|positive regulation of neuron projection development|
|renal system development|
|regulation of leukocyte cell-cell adhesion|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|regulation of T cell activation|
|urogenital system development|
|negative regulation of locomotion|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|regulation of cell-cell adhesion|
|morphogenesis of an epithelium|
|negative regulation of immune system process|
|positive regulation of neurogenesis|
|regulation of neuron projection development|
|cell-cell adhesion|
|negative regulation of intracellular signal transduction|
|regulation of lymphocyte activation|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell junction|
|tissue morphogenesis|
|regulation of leukocyte activation|
|regulation of cell activation|
|tube morphogenesis|
|regulation of neuron differentiation|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|brain development|
|head development|
|regulation of neurogenesis|
|tube development|
|regulation of cell migration|
|regulation of cell motility|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of intracellular signal transduction|
|epithelium development|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|generation of neurons|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-2.34|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-2.04|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-1.97|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.8|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.76|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.73|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10301
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DLG5 Expression in NALM6 Cells: 4.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>