======= DLL4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DLL4
  * **<color #00a2e8>Official Name</color>**: delta like canonical Notch ligand 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54567|54567]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NR61|Q9NR61]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DLL4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DLL4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605185|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344). {ECO:0000250|UniProtKB:Q9JI71, ECO:0000269|PubMed:11134954, ECO:0000269|PubMed:17728344, ECO:0000269|PubMed:20616313}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MNNL|
|EGF|
|DSL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|blood vessel lumenization|
|negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|
|regulation of neural retina development|
|regulation of retina development in camera-type eye|
|dorsal aorta morphogenesis|
|pericardium morphogenesis|
|dorsal aorta development|
|Notch signaling involved in heart development|
|endothelial tube morphogenesis|
|morphogenesis of an endothelium|
|regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|
|ventral spinal cord interneuron fate commitment|
|cell fate commitment involved in pattern specification|
|negative regulation of cell migration involved in sprouting angiogenesis|
|ventricular trabecula myocardium morphogenesis|
|ventral spinal cord interneuron differentiation|
|pericardium development|
|spinal cord dorsal/ventral patterning|
|cell surface receptor signaling pathway involved in heart development|
|negative regulation of sprouting angiogenesis|
|spinal cord patterning|
|Notch binding|
|branching involved in blood vessel morphogenesis|
|aorta morphogenesis|
|aortic valve morphogenesis|
|cardiac atrium morphogenesis|
|aortic valve development|
|heart trabecula morphogenesis|
|negative regulation of blood vessel endothelial cell migration|
|blood vessel remodeling|
|cardiac atrium development|
|semi-lunar valve development|
|negative regulation of endothelial cell proliferation|
|regulation of cell migration involved in sprouting angiogenesis|
|cellular response to vascular endothelial growth factor stimulus|
|negative regulation of Notch signaling pathway|
|trabecula morphogenesis|
|ventricular cardiac muscle tissue morphogenesis|
|ventral spinal cord development|
|morphogenesis of an epithelial sheet|
|negative regulation of endothelial cell migration|
|aorta development|
|positive regulation of Notch signaling pathway|
|positive regulation of neural precursor cell proliferation|
|heart valve morphogenesis|
|cell differentiation in spinal cord|
|ventricular cardiac muscle tissue development|
|artery morphogenesis|
|heart valve development|
|neuron fate commitment|
|negative regulation of epithelial cell migration|
|cardiac muscle tissue morphogenesis|
|regulation of sprouting angiogenesis|
|cardiac ventricle morphogenesis|
|muscle tissue morphogenesis|
|dorsal/ventral pattern formation|
|artery development|
|muscle organ morphogenesis|
|regulation of neural precursor cell proliferation|
|regulation of blood vessel endothelial cell migration|
|endothelium development|
|tissue remodeling|
|regulation of Notch signaling pathway|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|spinal cord development|
|cellular response to fibroblast growth factor stimulus|
|negative regulation of vasculature development|
|response to fibroblast growth factor|
|negative regulation of epithelial cell proliferation|
|Notch signaling pathway|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|regulation of endothelial cell proliferation|
|branching morphogenesis of an epithelial tube|
|T cell differentiation|
|regulation of endothelial cell migration|
|morphogenesis of a branching epithelium|
|cardiac muscle tissue development|
|morphogenesis of a branching structure|
|cardiac chamber development|
|central nervous system neuron differentiation|
|regulation of epithelial cell migration|
|visual perception|
|sensory perception of light stimulus|
|T cell activation|
|lymphocyte differentiation|
|cell fate commitment|
|heart morphogenesis|
|negative regulation of cell migration|
|negative regulation of cell motility|
|striated muscle tissue development|
|regulation of angiogenesis|
|muscle organ development|
|muscle tissue development|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|angiogenesis|
|regulation of vasculature development|
|negative regulation of locomotion|
|leukocyte differentiation|
|regionalization|
|regulation of epithelial cell proliferation|
|lymphocyte activation|
|blood circulation|
|circulatory system process|
|blood vessel morphogenesis|
|morphogenesis of an epithelium|
|pattern specification process|
|muscle structure development|
|blood vessel development|
|cellular response to growth factor stimulus|
|vasculature development|
|cardiovascular system development|
|heart development|
|response to growth factor|
|hemopoiesis|
|tissue morphogenesis|
|embryonic morphogenesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|tube morphogenesis|
|negative regulation of cell population proliferation|
|calcium ion binding|
|regulation of neurogenesis|
|tube development|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|sensory perception|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of signal transduction|
|negative regulation of gene expression|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|system process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14628
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DLL4 Expression in NALM6 Cells: 0.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>