======= DMAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DMAP1
  * **<color #00a2e8>Official Name</color>**: DNA methyltransferase 1 associated protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55929|55929]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NPF5|Q9NPF5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DMAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DMAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605077|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX- mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity. {ECO:0000269|PubMed:14665632, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:14978102, ECO:0000269|PubMed:15367675}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DMAP1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Swr1 complex|
|histone H2A acetylation|
|NuA4 histone acetyltransferase complex|
|replication fork|
|RNA polymerase II repressing transcription factor binding|
|positive regulation of protein import into nucleus|
|positive regulation of protein import|
|DNA methylation|
|DNA alkylation|
|histone exchange|
|histone H4 acetylation|
|regulation of protein import into nucleus|
|regulation of protein import|
|positive regulation of nucleocytoplasmic transport|
|DNA methylation or demethylation|
|positive regulation of protein localization to nucleus|
|ATP-dependent chromatin remodeling|
|DNA modification|
|regulation of nucleocytoplasmic transport|
|histone acetylation|
|regulation of protein localization to nucleus|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|response to ethanol|
|protein acetylation|
|positive regulation of intracellular protein transport|
|nucleosome organization|
|chromatin remodeling|
|protein acylation|
|positive regulation of intracellular transport|
|regulation of intracellular protein transport|
|response to alcohol|
|transcription corepressor activity|
|protein-DNA complex subunit organization|
|macromolecule methylation|
|response to antibiotic|
|methylation|
|peptidyl-lysine modification|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|histone modification|
|covalent chromatin modification|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|response to toxic substance|
|DNA repair|
|regulation of cellular protein localization|
|regulation of growth|
|chromatin organization|
|regulation of protein transport|
|regulation of peptide transport|
|DNA metabolic process|
|regulation of establishment of protein localization|
|cellular response to DNA damage stimulus|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|regulation of cellular localization|
|positive regulation of transport|
|response to drug|
|regulation of protein localization|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular response to stress|
|negative regulation of gene expression|
|protein-containing complex subunit organization|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 622/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|25/28|
|bone|22/25|
|breast|25/33|
|central nervous system|51/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|14/15|
|kidney|14/21|
|liver|18/20|
|lung|67/75|
|lymphocyte|14/14|
|ovary|22/26|
|pancreas|22/24|
|peripheral nervous system|13/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|5/7|
|thyroid|1/2|
|upper aerodigestive|19/22|
|urinary tract|24/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 758
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DMAP1 Expression in NALM6 Cells: 5.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>